Functional investigations on embryonic stem cells Labeled with clinically translatable iron oxide nanoparticles

	Functional investigations on embryonic stem cells Labeled with clinically translatable iron oxide nanoparticles
	Jing Liu; Liqin Wang; Jianbo Cao; Yue Huang; Yu Lin; Xiaoyun Wu; Zhiyong Wang; Fan Zhang; Xiuqin Xu; Gang Liu
刊名	NANOSCALE
	2014
英文摘要	Stem cell based therapies offer significant potential in the field of regenerative medicine. The development of superparamagnetic iron oxide (SPIO) nanoparticle labeling and magnetic resonance imaging (MRI) have been increasingly used to track the transplanted cells, enabling in vivo determination of cell fate. However, the impact of SPIO-labeling on the cell phenotype and differentiation capacity of embryonic stem cells (ESCs) remains unclear. In this study, we wrapped SPIO nanopartides with stearic acid grafted PEI600, termed as Stearic-LWPEI-SPIO, to generate efficient and non-toxic ESC labeling tools. Our results showed that efficient labeling of ESCs at an optimized low dosage of Stearic-LWPEI-SPIO nanoparticles did not alter the differentiation and self-renewal properties of ESCs. The localization of the transplanted ESCs observed by MRI correlated well with histological studies. These findings demonstrate that Stearic-LWPEI-SPIO nanoparticles have potential to be clinically translatable MRI probes and may enable noninvasive in vivo tracking of ESCs in experimental and clinical settings during cell-based therapies.
收录类别	SCI
原文出处	http://pubs.rsc.org/en/content/articlepdf/2014/nr/c4nr01004c
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/5740]
专题	深圳先进技术研究院_医工所
作者单位	NANOSCALE
推荐引用方式 GB/T 7714	Jing Liu,Liqin Wang,Jianbo Cao,et al. Functional investigations on embryonic stem cells Labeled with clinically translatable iron oxide nanoparticles[J]. NANOSCALE,2014.
APA	Jing Liu.,Liqin Wang.,Jianbo Cao.,Yue Huang.,Yu Lin.,...&Gang Liu.(2014).Functional investigations on embryonic stem cells Labeled with clinically translatable iron oxide nanoparticles.NANOSCALE.
MLA	Jing Liu,et al."Functional investigations on embryonic stem cells Labeled with clinically translatable iron oxide nanoparticles".NANOSCALE (2014).