Ferroelectric switching of elastin

	Ferroelectric switching of elastin
	Yuanming Liu; Hong-Ling Cai; Matthew Zelisko; Yunjie Wang; Jinglan Sun; Fei Yan; Feiyue Ma; Peiqi Wang; Qian Nataly Chen; Hairong Zheng
刊名	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
	2014
英文摘要	Ferroelectricity has long been speculated to have important biological functions, although its very existence in biology has never been firmly established. Here, we present compelling evidence that elastin, the key ECM protein found in connective tissues, is ferroelectric, and we elucidate the molecular mechanism of its switching. Nanoscale piezoresponse force microscopy and macroscopic pyroelectric measurements both show that elastin retains ferroelectricity at 473 K, with polarization on the order of 1 mu C/cm(2), whereas coarse-grained molecular dynamics simulations predict similar polarization with a Curie temperature of 580 K, which is higher than most synthetic molecular ferroelectrics. The polarization of elastin is found to be intrinsic in tropoelastin at the monomer level, analogous to the unit cell level polarization in classical perovskite ferroelectrics, and it switches via thermally activated cooperative rotation of dipoles. Our study sheds light onto a long-standing question on ferroelectric switching in biology and establishes ferroelectricity as an important biophysical property of proteins. This is a critical first step toward resolving its physiological significance and pathological implications.
收录类别	SCI
原文出处	http://www.pnas.org/content/111/27/E2780.full.pdf
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/5739]
专题	深圳先进技术研究院_医工所
作者单位	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
推荐引用方式 GB/T 7714	Yuanming Liu,Hong-Ling Cai,Matthew Zelisko,et al. Ferroelectric switching of elastin[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2014.
APA	Yuanming Liu.,Hong-Ling Cai.,Matthew Zelisko.,Yunjie Wang.,Jinglan Sun.,...&Jiangyu Li.(2014).Ferroelectric switching of elastin.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
MLA	Yuanming Liu,et al."Ferroelectric switching of elastin".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014).