Detection of Subclinical Atherosclerosis in Asymptomatic Subjects Using Ultrasound Radiofrequency-Tracking Technology

	Detection of Subclinical Atherosclerosis in Asymptomatic Subjects Using Ultrasound Radiofrequency-Tracking Technology
	Lili Niu; Yanling Zhang; , Long Meng; Yang Xiao; Kelvin K. L. Wong; Derek Abbott; Hairong Zheng; Rongqin Zheng; Ming Qian
刊名	PLOS ONE
	2014
英文摘要	Objective: Atherosclerosis is a chronic and systemic disease and its developmental process involves the synergism of multiple risk factors such as hypertension, dyslipidemia, diabetes, obesity and smoking. The diagnosis of subclinical atherosclerosis is essential for strategic guidance towards suitable treatments and efficient prevention against acute cardiovascular events. This study employed ultrasound radiofrequency (RF) tracking technology to characterize human carotid arteries in vivo in terms of intima-media thickness (IMT) and artery stiffness, and evaluated the statistical correlation between carotid IMT and stiffness, and the number of risk factors for atherosclerosis. Methods: A total of 160 asymptomatic subjects were enrolled. Ultrasound RF-tracking technology was employed to acquire carotid IMT and stiffness parameters: maximum IMT (MAXIMT), RF Quality IMT (RFQIMT), distensibility coefficient (DC), compliance coefficient (CC), aindex, b index and local pulse wave velocity (PWVb). The subjects were categorized in four groups in terms of the number of risk factors: ‘zero’, ‘single’, ‘double’, and ‘multiple’, and statistical analyses of carotid IMT and stiffness parameters were performed between these different groups. Results: The subjects (n = 145) with MAXIMT smaller than 1.0 mm matched the IMT criteria for non-atherosclerosis and were named as NA-subjects. Spearman’s rho correlation analysis of the whole group and the NA-subjects both showed that MAXIMT correlated positively with RFQIMT, a, b, and PWVb, and negatively with DC and CC (p,0.01). The analysis of covariance of NA-subjects showed significant differences between subjects with and without risk factors, and also showed significant differences between the ‘zero’, ‘single’, ‘double’, and ‘multiple’ groups. Conclusions: The carotid IMT and stiffness parameters obtained by the ultrasound RF-tracking technology were demonstrated to possess significant statistical correlation with the number of risk factors from 160 subjects, and these anatomical and mechanical parameters may potentially be used together with the IMT criteria to support subclinical atherosclerosis diagnosis.
收录类别	SCI
原文出处	http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0111926&representation=PDF
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/5738]
专题	深圳先进技术研究院_医工所
作者单位	PLOS ONE
推荐引用方式 GB/T 7714	Lili Niu,Yanling Zhang,, Long Meng,et al. Detection of Subclinical Atherosclerosis in Asymptomatic Subjects Using Ultrasound Radiofrequency-Tracking Technology[J]. PLOS ONE,2014.
APA	Lili Niu.,Yanling Zhang.,, Long Meng.,Yang Xiao.,Kelvin K. L. Wong.,...&Ming Qian.(2014).Detection of Subclinical Atherosclerosis in Asymptomatic Subjects Using Ultrasound Radiofrequency-Tracking Technology.PLOS ONE.
MLA	Lili Niu,et al."Detection of Subclinical Atherosclerosis in Asymptomatic Subjects Using Ultrasound Radiofrequency-Tracking Technology".PLOS ONE (2014).