A numerical study of the effect of varied blood pressure on the stability of carotid atherosclerotic plaque

	A numerical study of the effect of varied blood pressure on the stability of carotid atherosclerotic plaque
	Huahua Xiong; Xin Liu; Xiaohong Tian; Lina Pu; Heye Zhang; Minhua Lu; Wenhua Huang; Yuan-Ting Zhang
刊名	BIOMEDICAL ENGINEERING ONLINE
	2014
英文摘要	Background: Blood pressure (BP) is associated with early atherosclerosis and plaque rupture because the BP variability can significantly affect the blood flow velocity and shear stress over the plaque. However, the mechanical response of BP variability to the plaque remains unclear. Therefore, we investigated the correlation between different maximum systolic blood pressure (SBP) and the stress distribution on plaque, as well as the stress over the plaque and blood velocity around the plaque using different BP variations, which are the BP variability in different phases during one cardiac cycle and beat-to-beat BP variability. Method: We established a two-dimensional artery model with stenosis at the degree of 62.5%. Eight combinations of pulsatile pressure gradients between the inflow and outflow were implemented at the model. Three levels of fibrous cap thickness were taken into consideration to investigate the additional effect on the BP variability. Wall shear stress and stress/strain distribution over the plaque were derived as well as the oscillation shear index (OSI) to analyze the impact of the changing rate of BP. Result: The stresses at diastole were 2.5% ± 1.8% lower than that at systole under the same pressure drop during one cycle. It was also found that elevated SBP might cause the immediate increment of stress in the present cycle (292% ± 72.3%), but slight reduction in the successive cycle (0.48% ± 0.4%). Conclusion: The stress/strain distribution over the plaque is sensitive to the BP variability during one cardiac cycle, and the beat-to-beat BP variability could cause considerable impact on the progression of atherosclerosis in long-term.
收录类别	SCI
原文出处	http://www.biomedical-engineering-online.com/content/pdf/1475-925X-13-152.pdf
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/5705]
专题	深圳先进技术研究院_医工所
作者单位	BIOMEDICAL ENGINEERING ONLINE
推荐引用方式 GB/T 7714	Huahua Xiong,Xin Liu,Xiaohong Tian,et al. A numerical study of the effect of varied blood pressure on the stability of carotid atherosclerotic plaque[J]. BIOMEDICAL ENGINEERING ONLINE,2014.
APA	Huahua Xiong.,Xin Liu.,Xiaohong Tian.,Lina Pu.,Heye Zhang.,...&Yuan-Ting Zhang.(2014).A numerical study of the effect of varied blood pressure on the stability of carotid atherosclerotic plaque.BIOMEDICAL ENGINEERING ONLINE.
MLA	Huahua Xiong,et al."A numerical study of the effect of varied blood pressure on the stability of carotid atherosclerotic plaque".BIOMEDICAL ENGINEERING ONLINE (2014).