Hypoxia-Inducible Factor: A Potential Therapeutic Target for Rheumatoid Arthritis

	Hypoxia-Inducible Factor: A Potential Therapeutic Target for Rheumatoid Arthritis
	Zhao,Xuli; Yue,Ye; Cheng,Wengxiang; Li,Jingchao; Hu,Yiping; qin,Ling; Zhang,Peng
刊名	CURRENT DRUG TARGETS
	2013
英文摘要	The hypoxic microenvironment is a clinicopathological characteristic of many diseases, such as rheumatoid arthritis (RA). As a transcription factor activating the gene expression involved in processes such as cell metabolism and angiogenesis, hypoxia-inducible factor (HIF) has a central function in adaption to altered oxygen tension and even contributes to the progression of related diseases. In RA, HIF induces angiogenesis, cell migration, and cartilage destruction, inhibits the apoptosis of synovial cells and inflammatory cells and initiates glycolysis for energy supply by upregulating specific protein levels. HIF expression in RA can be regulated in both oxygen-dependent and independent fashions, leading to the aggravation of this disease. Therefore, HIF is one of the vital RA mediators. Based on the application of HIF-targeted drug research and development in tumors, HIF is a potential therapeutic target for treating RA.
收录类别	SCI
原文出处	http://chinesesites.library.ingentaconnect.com/content/ben/cdt/2013/00000014/00000006/art00010
语种	英语
WOS记录号	WOS:000318689000010
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/4894]
专题	深圳先进技术研究院_医工所
作者单位	CURRENT DRUG TARGETS
推荐引用方式 GB/T 7714	Zhao,Xuli,Yue,Ye,Cheng,Wengxiang,et al. Hypoxia-Inducible Factor: A Potential Therapeutic Target for Rheumatoid Arthritis[J]. CURRENT DRUG TARGETS,2013.
APA	Zhao,Xuli.,Yue,Ye.,Cheng,Wengxiang.,Li,Jingchao.,Hu,Yiping.,...&Zhang,Peng.(2013).Hypoxia-Inducible Factor: A Potential Therapeutic Target for Rheumatoid Arthritis.CURRENT DRUG TARGETS.
MLA	Zhao,Xuli,et al."Hypoxia-Inducible Factor: A Potential Therapeutic Target for Rheumatoid Arthritis".CURRENT DRUG TARGETS (2013).