Self-assembled magnetic theranostic nanoparticles for highly sensitive MRI of minicircle DNA delivery

	Self-assembled magnetic theranostic nanoparticles for highly sensitive MRI of minicircle DNA delivery
	Qian Wan; Lisi Xie; Lin Gao; Zhiyong Wang; Xiang Nan; Hulong Lei; Xiaojing Long; Zhi-Ying Chen; Cheng-Yi He; Gang Liu
刊名	NANOSCALE
	2013
英文摘要	As a versatile gene vector, minicircle DNA (mcDNA) has a great potential for gene therapy. However, some serious challenges remain, such as to effectively deliver mcDNA into targeted cells/tissues and to non-invasively monitor the delivery of the mcDNA. Superparamagnetic iron oxide (SPIO) nanoparticles have been extensively used for both drug/gene delivery and diagnosis. In this study, an MRI visible gene delivery system was developed with a core of SPIO nanocrystals and a shell of biodegradable stearic acid-modified low molecular weight polyethyleneimine (Stearic-LWPEI) via self-assembly. The Stearic-LWPEI-SPIO nanoparticles possess a controlled clustering structure, narrow size distribution and ultrasensitive imaging capacity. Furthermore, the nanoparticle can effectively bind with mcDNA and protect it from enzymatic degradation. In conclusion, the nanoparticle shows synergistic advantages in the effective transfection of mcDNA and non-invasive MRI of gene delivery.
收录类别	SCI
原文出处	http://pubs.rsc.org/en/content/articlehtml/2013/nr/c2nr32438e
语种	英语
WOS记录号	WOS:000313426200039
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/4752]
专题	深圳先进技术研究院_医工所
作者单位	NANOSCALE
推荐引用方式 GB/T 7714	Qian Wan,Lisi Xie,Lin Gao,et al. Self-assembled magnetic theranostic nanoparticles for highly sensitive MRI of minicircle DNA delivery[J]. NANOSCALE,2013.
APA	Qian Wan.,Lisi Xie.,Lin Gao.,Zhiyong Wang.,Xiang Nan.,...&Bensheng Qiu.(2013).Self-assembled magnetic theranostic nanoparticles for highly sensitive MRI of minicircle DNA delivery.NANOSCALE.
MLA	Qian Wan,et al."Self-assembled magnetic theranostic nanoparticles for highly sensitive MRI of minicircle DNA delivery".NANOSCALE (2013).