Three-dimensional high frequency power Doppler ultrasonography for the assessment of microvasculature during fracture healing in a rat model

	Three-dimensional high frequency power Doppler ultrasonography for the assessment of microvasculature during fracture healing in a rat model
	Ming-Hui Sun; Kwok-Sui Leung; Yong-Ping Zheng; Yan-Ping Huang; Li-Ke Wang; Ling Qin; Andraay Hon-Chi Leung; Simon Kwoon-Ho Chow; Wing-Hoi Cheung
刊名	JOURNAL OF ORTHOPAEDIC RESEARCH
	2012
英文摘要	We aimed to establish a novel approach with 3D high frequency power Doppler ultrasonography (3D-HF-PDU) to assess microvasculature at the fracture site in rat femurs by comparing with microCT-based microangiography. Twenty-four 9-month-old ovariectomized (OVX) osteoporotic rats and age-matched sham-ovariectomized (Sham) rats were used for establishing closed fracture models on right femora. At 2, 4, and 8 weeks post-operatively, four rats in each group underwent in vivo 3D-HF-PDU scanning for evaluation of vascularization and blood flow at the fracture site. Then the fractured femora were harvested for ex vivo microangiography, and neovasculatures within the callus were reconstructed for vascular volume analysis. Correlation between the vascular volumes of the two methodologies was examined. Both 3D-HF-PDU and microangiography showed a decline of vascular volume at the fracture site from 2 to 8 weeks and a significantly larger volume in the Sham group than the OVX group. A significant linear positive correlation (r?=?0.87, p?
收录类别	SCI
原文出处	http://onlinelibrary.wiley.com/doi/10.1002/jor.21490/pdf
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/4016]
专题	深圳先进技术研究院_医工所
作者单位	JOURNAL OF ORTHOPAEDIC RESEARCH
推荐引用方式 GB/T 7714	Ming-Hui Sun,Kwok-Sui Leung,Yong-Ping Zheng,et al. Three-dimensional high frequency power Doppler ultrasonography for the assessment of microvasculature during fracture healing in a rat model[J]. JOURNAL OF ORTHOPAEDIC RESEARCH,2012.
APA	Ming-Hui Sun.,Kwok-Sui Leung.,Yong-Ping Zheng.,Yan-Ping Huang.,Li-Ke Wang.,...&Wing-Hoi Cheung.(2012).Three-dimensional high frequency power Doppler ultrasonography for the assessment of microvasculature during fracture healing in a rat model.JOURNAL OF ORTHOPAEDIC RESEARCH.
MLA	Ming-Hui Sun,et al."Three-dimensional high frequency power Doppler ultrasonography for the assessment of microvasculature during fracture healing in a rat model".JOURNAL OF ORTHOPAEDIC RESEARCH (2012).