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	Study in Treatment of Collagen-Induced Arthritis in DBA/1 Mouse by Genistein
	hu yiping; yue ye; cheng wenxiang; wang jie; ma yingya; zhang peng
	2015
会议名称	2015 International Children Medical Research Society（ICMRS 2015）
会议地点	长沙
英文摘要	Objection: Rheumatoid arthritis (RA) is characterized by the chronic inflammation of synovial tissues and the destruction of bone and cartilage. Genistein, an isoflavone derivative found in soy, is known as a promising treatment for rheumatoid arthritis (RA). The aim of this work was to evaluate the effecting of genistein treatment of Collagen-Induced Arthritis in rat by. Methods: To observe the effect of genistein, after the onset of arthritis, the animal were divided into two groups based on their clinical symptoms score. One group were intraperitoneally (IP) injected daily with genistein (5mg/kg) for ten days; whereas phosphate buffered saline (PBS) was used for the control group. Cytokine titers, radiological, and histological examinations were performed at different time points after treatment with genistein. Results: Genistein decreased the secretion of IL-1β, IL-6, TNF-α in the serum compared with control group. In addition, radiological results show that bone degradation was inhibited. Moreover, the hematoxylin and eosin (H&E) staining degree of inflammation was significantly alleviated. Tartrate-resistant acid phosphatase (TRAP) stain-positive cells were also detected in the destruction of the articular cartilage, which was significantly reduced compared with the control group. Conclusion: This study provides the further evidence on the effect of genistein as a potential treatment for RA and to the role of the anti-inflammatory pathway in RA therapy.
收录类别	其他
语种	英语
内容类型	会议论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/7307]
专题	深圳先进技术研究院_医工所
作者单位	2015
推荐引用方式 GB/T 7714	hu yiping,yue ye,cheng wenxiang,et al. Study in Treatment of Collagen-Induced Arthritis in DBA/1 Mouse by Genistein[C]. 见:2015 International Children Medical Research Society（ICMRS 2015）. 长沙.

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