Structural, densitometric and biomechanical evaluations of Chinese patients with long-term bisphosphonate treatment

	Structural, densitometric and biomechanical evaluations of Chinese patients with long-term bisphosphonate treatment
	Leung Kwok-sui; Tang Ning; Griffith James; Choy Tak-Kee; Hung Vivian Wing-Yin; Mok Hoi-Wa; Shi Lin; Leung Ping-Chung; Cheung Wing-Hoi
刊名	CHINESE MEDICAL JOURNAL
	2013
英文摘要	Background The association of long-term bisphosphonate treatment for osteoporosis and related safety problems such as atypical fractures were not clearly defined. This study was to evaluate the structural, densitometric and biomechanical properties of the prolonged bisphosphonate-loaded bones. Methods Bone mineral density (BMD) at hip and femoral midshaft, bone cross-sectional area, moment of inertia of both femurs, bone formation and resorption biochemical markers were compared between 28 elderly with at least 4 years of bisphosphonate treatment from 2002 through 2006 and age-matched group of37 elderly. Results The total hip BMD and t-score were found not different between two groups. However, bisphosphonate treated patients were found to have significantly lower bone mineral content in the femoral shaft (P<0.05); morphological study showed lower cross-sectional area in subtrochanteric and mid-diaphyseal region and thus significantly lower moment of inertia (P<0.01). High resolution-peripheral quantitative computed tomography showed significantly decreased trabeculardensity, bone volume ratio, trabecular number but increased trabecular spacing in tibia and distal radius. Finite element analysis further confirmed significantly lower stiffness and failure load in tibia. Biochemical studies also showed lower bone resorption and severely suppressed bone formation activity (P<0.001). Conclusions The unchanged total hip BMD between two groups confirmed the beneficial effects of bisphosphonate on trabecular bone, thus preventing osteoporotic fractures at large in previous studies. However, the inferior structural, densitometric and biomechanical properties at cortical bones, especially femur midshaft, need a special attention to look into the association between long-term bisphosphonate intake and the occurrence of stress fractures. Whenpatients taking bisphosphonate complain of proximal thigh pain or discomfort, plain X-ray film can be the first line screening. All patients prescribed withbisphosphonate should be informed of such a complication though we must stress its rarity.
收录类别	SCI
原文出处	http://f.wanfangdata.com.cn/view/Structural,%20densitometric%20and%20biomechanical%20evaluations%20of%20Chinese%20patients%20with%20long-term%20bisphosphonate%20treatment.aspx?ID=Periodical_zhcmj201301006&transaction=%7b"ExtraData"%3a%5b%5d%2c"IsCache"%3afalse%2c"Transaction"%3a%7b"DateTime"%3a"%5c%2fDate(1437360912062%2b0800)%5c%2f"%2c"Id"%3a"3fff9698-e1d0-486b-af74-a4db00b3f4d3"%2c"Memo"%3anull%2c"ProductDetail"%3a"Periodical_zhcmj201301006"%2c"SessionId"%3a"78fd200f-29b0-4157-a761-d56f97c778dd"%2c"Signature"%3a"dVBzW%2bQe2dm4nHjpsRvmtu%5c%2frdK7EGN9%2bMbFNmKeTLFMXVlvEh02SjNoIODajlwQI"%2c"TransferIn"%3a%7b"AccountType"%3a"Income"%2c"Key"%3a"PeriodicalFulltext"%7d%2c"TransferOut"%3a%7b"AccountType"%3a"GTimeLimit"%2c"Key"%3a"szdxc"%7d%2c"Turnover"%3a3.00000%2c"User"%3anull%2c"UserIP"%3a"210.75.252.209"%7d%2c"TransferOutAccountsStatus"%3a%5b%5d%7d
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/5261]
专题	深圳先进技术研究院_其他
作者单位	CHINESE MEDICAL JOURNAL
推荐引用方式 GB/T 7714	Leung Kwok-sui,Tang Ning,Griffith James,et al. Structural, densitometric and biomechanical evaluations of Chinese patients with long-term bisphosphonate treatment[J]. CHINESE MEDICAL JOURNAL,2013.
APA	Leung Kwok-sui.,Tang Ning.,Griffith James.,Choy Tak-Kee.,Hung Vivian Wing-Yin.,...&Cheung Wing-Hoi.(2013).Structural, densitometric and biomechanical evaluations of Chinese patients with long-term bisphosphonate treatment.CHINESE MEDICAL JOURNAL.
MLA	Leung Kwok-sui,et al."Structural, densitometric and biomechanical evaluations of Chinese patients with long-term bisphosphonate treatment".CHINESE MEDICAL JOURNAL (2013).