Identification and Pharmacokinetics of Multiple Potential Bioactive Constituents after Oral Administration of Radix Astragali on Cyclophosphamide-Induced Immunosuppression in Balb/c Mice

	Identification and Pharmacokinetics of Multiple Potential Bioactive Constituents after Oral Administration of Radix Astragali on Cyclophosphamide-Induced Immunosuppression in Balb/c Mice
	Menghua Liu; Panlin Li; Xuan Zeng; Huanxian Wu; Weiwei Su; Jingyu He
刊名	International Journal of Molecular Sciences
	2015
英文摘要	Radix Astragali (RA) is one of the commonly-used traditional Chinese medicines (TCMs) with an immunomodulatory effect confirmed in the clinic. In order to better understand the material basis for the therapeutic effects, this study was to investigate the absorbed components and their pharmacokinetic profile after oral administration of RA on cyclophosphamide-induced immunosuppression in Balb/c mice. As a result, 51 compounds in RA extract and 31 prototype compounds with nine metabolites were detected in mice plasma by the ultra-fast liquid chromatography (UFLC)-DAD-Q-TOF-MS/MS method. The pharmacokinetic parameters of five main constituents, including calycosin-7-O-glucoside,ononin, calycosin, formononetin and astragaloside IV, were obtained using HPLC-MS/MS. These results offered useful information for research on the pharmacological mechanism of RA and for its further development.
收录类别	SCI
原文出处	http://www.mdpi.com/1422-0067/16/3/5047
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/7545]
专题	深圳先进技术研究院_南沙所
作者单位	International Journal of Molecular Sciences
推荐引用方式 GB/T 7714	Menghua Liu,Panlin Li,Xuan Zeng,et al. Identification and Pharmacokinetics of Multiple Potential Bioactive Constituents after Oral Administration of Radix Astragali on Cyclophosphamide-Induced Immunosuppression in Balb/c Mice[J]. International Journal of Molecular Sciences,2015.
APA	Menghua Liu,Panlin Li,Xuan Zeng,Huanxian Wu,Weiwei Su,&Jingyu He.(2015).Identification and Pharmacokinetics of Multiple Potential Bioactive Constituents after Oral Administration of Radix Astragali on Cyclophosphamide-Induced Immunosuppression in Balb/c Mice.International Journal of Molecular Sciences.
MLA	Menghua Liu,et al."Identification and Pharmacokinetics of Multiple Potential Bioactive Constituents after Oral Administration of Radix Astragali on Cyclophosphamide-Induced Immunosuppression in Balb/c Mice".International Journal of Molecular Sciences (2015).