3D plotting of highly uniform Sr-5(PO4)(2)SiO4 bioceramic scaffolds for bone tissue engineering | |
Zhu, Huiying; Zhai, Dong; Lin, Chucheng; Zhang, Yali; Huan, Zhiguang; Chang, Jiang; Wu, Chengtie | |
刊名 | JOURNAL OF MATERIALS CHEMISTRY B |
2016 | |
卷号 | 4期号:37页码:6200-6212 |
英文摘要 | Bioceramics play an important role in bone regeneration. However, it is challenging to design bioceramic scaffolds with suitable ionic components and beneficial osteo/angio-stimulation ability for enhanced bone regeneration. In this study, we successfully synthesized a pure-phase Sr-5(PO4)(2)SiO4 (SPS) bioactive ceramic through a solid-state reaction method and further prepared highly uniform SPS bioceramic scaffolds with controlled macropore sizes and mechanical strength by a 3D-plotting technique, and the biological responses of rabbit bone marrow stromal cells (rBMSCs) and human umbilical vein endothelial cells (HUVECs) after culturing with different concentrations of SPS extracts and porous scaffolds were systematically studied. The results showed that the ionic products from SPS bioceramics significantly stimulated the proliferation, alkaline phosphate (ALP) activity and osteogenesis-related gene expression (Runx2, ALP, OCN, OPN) of rBMSCs as well as the proliferation and angiogenesis-related gene expression (VEGF, KDR, eNOS, HIF 1 alpha) of HUVECs. 3D-plotted SPS scaffolds could effectively support the attachment and proliferation of both rBMSCs and HUVECs, and the proliferation rates of the two kinds of cells in SPS scaffolds were distinctively higher than those in beta-tricalcium phosphate (beta-TCP) scaffolds prepared by the same method. In addition, the compressive strength of SPS scaffolds could be well controlled in the range 8-30 MPa when their pore size varied from 100 to 300 mu m, which was significantly higher than those of beta-TCP scaffolds with similar pore sizes (similar to 1.5 times). Our results demonstrated that 3D-plotted SPS bioceramic scaffolds with such a specific ionic combination and high mechanical strength as well as good degradability possessed the ability to stimulate both osteogenic and angiogenic differentiation of tissue cells, indicating that they might be promising biomaterials for bone tissue engineering. |
WOS标题词 | Science & Technology ; Technology |
类目[WOS] | Materials Science, Biomaterials |
研究领域[WOS] | Materials Science |
关键词[WOS] | MESENCHYMAL STEM-CELLS ; SILICATE BIOACTIVE CERAMICS ; MARROW STROMAL CELLS ; IN-VITRO ; CALCIUM SILICATE ; STRONTIUM RANELATE ; IONIC PRODUCTS ; OSTEOBLASTIC DIFFERENTIATION ; POROUS HYDROXYAPATITE ; GLASS SCAFFOLDS |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000384444800005 |
内容类型 | 期刊论文 |
源URL | [http://ir.sic.ac.cn/handle/331005/22131] |
专题 | 上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文 |
作者单位 | Chinese Acad Sci, State Key Lab High Performance Ceram & Superfine, Shanghai Inst Ceram, 1295 Dingxi Rd, Shanghai 200050, Peoples R China |
推荐引用方式 GB/T 7714 | Zhu, Huiying,Zhai, Dong,Lin, Chucheng,et al. 3D plotting of highly uniform Sr-5(PO4)(2)SiO4 bioceramic scaffolds for bone tissue engineering[J]. JOURNAL OF MATERIALS CHEMISTRY B,2016,4(37):6200-6212. |
APA | Zhu, Huiying.,Zhai, Dong.,Lin, Chucheng.,Zhang, Yali.,Huan, Zhiguang.,...&Wu, Chengtie.(2016).3D plotting of highly uniform Sr-5(PO4)(2)SiO4 bioceramic scaffolds for bone tissue engineering.JOURNAL OF MATERIALS CHEMISTRY B,4(37),6200-6212. |
MLA | Zhu, Huiying,et al."3D plotting of highly uniform Sr-5(PO4)(2)SiO4 bioceramic scaffolds for bone tissue engineering".JOURNAL OF MATERIALS CHEMISTRY B 4.37(2016):6200-6212. |
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