Peroxidase-Like Activity of Ethylene Diamine Tetraacetic Acid and Its Application for Ultrasensitive Detection of Tumor Biomarkers and Circular Tumor Cells

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 生物材料与组织工程研究中心 > 期刊论文

	Peroxidase-Like Activity of Ethylene Diamine Tetraacetic Acid and Its Application for Ultrasensitive Detection of Tumor Biomarkers and Circular Tumor Cells
	Huang, Haowen 1; Liu, Lanfang 1; Zhang, Lingyang 1; Zhao, Qjan 1; Zhou, Yuan 1; Yuan, Shishan 2; Tang, Zilong 1; Liu, Xuanyong 3
刊名	ANALYTICAL CHEMISTRY
	2017-01-03
卷号	89 期号:1 页码:666-672
英文摘要	Ethylene diamine tetraacetic acid (EDTA) is such a powerful chelating agent that it may form stable complexes with most metal ions, which has wide applications in industry, agriculture, environment, and pharmaceutical technology. Recently, EDTA was found to enhance the photocatalytic property of some materials. Inspired by this fact of EDTA in the photocatalytic role, we further investigated the photocatalytic property of EDTA and found much the same as that of natural horseradish peroxidase (HRP). This significant discovery of peroxidase-like property may extend the applications of conventional EDTA in life science. A novel and colorimetric sensor based on the peroxidase-like EDTA and unique gold nanorods (GNRs) was designed. Under light irradiation, EDTA may catalyze decomposition of hydrogen peroxide and in situ regulate the longitudinal plasmon wavelength (LPW) of GNRs, displaying various color solution as a read-out means. This colorimetric nanosensor has a great potential to develop into a platform to quantitatively determine aualytes as long as the specific antibodies against them were available. Biomarkers of different diseases, such as breast cancer and prostate cancer, were detected with high accuracy. Moreover, combined with immunomagnetic separation of circulating tumor cells (CTCs) from blood, a visual read-out for detection of CTCs was established, which has promising applications in clinical diagnosis, environmental monitoring, and food quality control only using naked eyes.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Analytical
研究领域[WOS]	Chemistry
关键词[WOS]	LINKED-IMMUNOSORBENT-ASSAY ; ENHANCED PHOTOCATALYTIC ACTIVITY ; METASTATIC BREAST-CANCER ; WASTE-WATER ; NAKED-EYE ; EDTA ; SURVIVAL ; GROWTH ; COPPER ; ELISA
收录类别	SCI
语种	英语
WOS记录号	WOS:000391346600051
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/21896]
专题	上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文
作者单位	1.Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Theoret Organ Chem & Funct Mol, Minist Educ,Hunan Prov Univ Key Lab,QSAR,QSPR, Xiangtan 411201, Peoples R China 2.Hunan Normal Univ, Sch Med, Changsha 410006, Hunan, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
推荐引用方式 GB/T 7714	Huang, Haowen,Liu, Lanfang,Zhang, Lingyang,et al. Peroxidase-Like Activity of Ethylene Diamine Tetraacetic Acid and Its Application for Ultrasensitive Detection of Tumor Biomarkers and Circular Tumor Cells[J]. ANALYTICAL CHEMISTRY,2017,89(1):666-672.
APA	Huang, Haowen.,Liu, Lanfang.,Zhang, Lingyang.,Zhao, Qjan.,Zhou, Yuan.,...&Liu, Xuanyong.(2017).Peroxidase-Like Activity of Ethylene Diamine Tetraacetic Acid and Its Application for Ultrasensitive Detection of Tumor Biomarkers and Circular Tumor Cells.ANALYTICAL CHEMISTRY,89(1),666-672.
MLA	Huang, Haowen,et al."Peroxidase-Like Activity of Ethylene Diamine Tetraacetic Acid and Its Application for Ultrasensitive Detection of Tumor Biomarkers and Circular Tumor Cells".ANALYTICAL CHEMISTRY 89.1(2017):666-672.