Cetylpyridinium chloride mouth rinses alleviate experimental gingivitis by inhibiting dental plaque maturation

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	Cetylpyridinium chloride mouth rinses alleviate experimental gingivitis by inhibiting dental plaque maturation
	Teng, Fei 1,2,3; He, Tao 4; Huang, Shi 2,3,5; Bo, Cun-Pei 2,3; Li, Zhen 6; Chang, Jin-Lan 7; Liu, Ji-Quan 8; Charbonneau, Duane 4; Xu, Jian 2,3; Li, Rui 8
刊名	INTERNATIONAL JOURNAL OF ORAL SCIENCE
	2016-09-01
卷号	8 期号:3 页码:182-190
关键词	cetylpyridinium chloride oral microbiota oral rinse
英文摘要	Oral rinses containing chemotherapeutic agents, such as cetylpyridinium chloride (CPC), can alleviate plaque-induced gingival infections, but how oral microbiota respond to these treatments in human population remains poorly understood. Via a double blinded, randomised controlled trial of 91 subjects, the impact of CPC-containing oral rinses on supragingival plaque was investigated in experimental gingivitis, where the subjects, after a 21-day period of dental prophylaxis to achieve healthy gingivae, received either CPC rinses or water for 21 days. Within-subject temporal dynamics of plaque microbiota and symptoms of gingivitis were profiled via 16S ribosomal DNA gene pyrosequencing and assessment with the Mazza gingival index. Cetylpyridinium chloride conferred gingival benefits, as progression of gingival inflammation resulting from a lack of dental hygiene was significantly slower in the mouth rinse group than in the water group due to inhibition of 17 gingivitis-enriched bacterial genera. Tracking of plaque alpha and beta diversity revealed that CPC treatment prevents acquisition of new taxa that would otherwise accumulate but maintains the original biodiversity of healthy plaques. Furthermore, CPC rinses reduced the size, local connectivity and microbiota-wide connectivity of the bacterial correlation network, particularly for nodes representing gingivitis enriched taxa. The findings of this study provide mechanistic insights into the impact of oral rinses on the progression and maturation of dental plaque in the natural human population.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Dentistry, Oral Surgery & Medicine
研究领域[WOS]	Dentistry, Oral Surgery & Medicine
关键词[WOS]	IN-VITRO ; ANTIMICROBIAL MOUTHRINSES ; ORAL MICROBIOTA ; EFFICACY ; HEALTH ; ANTIBACTERIAL ; PERIODONTITIS ; BIOFILMS ; DISEASES ; COMMUNITIES
收录类别	SCI
语种	英语
WOS记录号	WOS:000385468800007
内容类型	期刊论文
源URL	[http://ir.qibebt.ac.cn/handle/337004/9060]
专题	青岛生物能源与过程研究所_单细胞中心
作者单位	1.Sun Yat Sen Univ, Guanghua Sch & Hosp Stomatol, Dept Operat Dent & Endodont, Guangzhou 510055, Guangdong, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Single Cell Ctr, Qingdao, Peoples R China 3.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Shandong Key Lab Energy Genet, Qingdao, Peoples R China 4.Procter & Gamble Mason Business Ctr, Dept Oral Care Clin Operat, Cincinnati, OH USA 5.Univ Chinese Acad Sci, Sino Danish Ctr Educ & Res, Beijing, Peoples R China 6.Beijing Union Med Coll Hosp, Dept Stomatol, Beijing, Peoples R China 7.Procter & Gamble Innovat Ctr, Global Microbiol Capabil Org, Beijing, Peoples R China 8.Procter & Gamble Int Operat SA, Global Microbiol Capabil Org, Singapore Branch, Singapore 138547, Singapore
推荐引用方式 GB/T 7714	Teng, Fei,He, Tao,Huang, Shi,et al. Cetylpyridinium chloride mouth rinses alleviate experimental gingivitis by inhibiting dental plaque maturation[J]. INTERNATIONAL JOURNAL OF ORAL SCIENCE,2016,8(3):182-190.
APA	Teng, Fei.,He, Tao.,Huang, Shi.,Bo, Cun-Pei.,Li, Zhen.,...&Ling, Jun-Qi.(2016).Cetylpyridinium chloride mouth rinses alleviate experimental gingivitis by inhibiting dental plaque maturation.INTERNATIONAL JOURNAL OF ORAL SCIENCE,8(3),182-190.
MLA	Teng, Fei,et al."Cetylpyridinium chloride mouth rinses alleviate experimental gingivitis by inhibiting dental plaque maturation".INTERNATIONAL JOURNAL OF ORAL SCIENCE 8.3(2016):182-190.