BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development

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	BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development
	Zhou, Wenwen 1,2; He, Qiuping 2,3; Zhang, Chunxia 2,3; He, Xin 1; Cui, Zongbin 4; Liu, Feng 2,3; Li, Wei 1,5,6,7,8
刊名	ELIFE
	2016-10-10
卷号	5
ISSN号	2050-084X
英文摘要	Notch signaling plays a crucial role in controling the proliferation and differentiation of stem and progenitor cells during embryogenesis or organogenesis, but its regulation is incompletely understood. BLOS2, encoded by the Bloc1s2 gene, is a shared subunit of two lysosomal trafficking complexes, biogenesis of lysosome-related organelles complex-1 (BLOC-1) and BLOC-1-related complex (BORC). Bloc1s2(-/-) mice were embryonic lethal and exhibited defects in cortical development and hematopoiesis. Loss of BLOS2 resulted in elevated Notch signaling, which consequently increased the proliferation of neural progenitor cells and inhibited neuronal differentiation in cortices. Likewise, ablation of bloc1s2 in zebrafish or mice led to increased hematopoietic stem and progenitor cell production in the aorta-gonad-mesonephros region. BLOS2 physically interacted with Notch1 in endo-lysosomal trafficking of Notch1. Our findings suggest that BLOS2 is a novel negative player in regulating Notch signaling through lysosomal trafficking to control multiple stem and progenitor cell homeostasis in vertebrates.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biology
研究领域[WOS]	Life Sciences & Biomedicine - Other Topics
关键词[WOS]	LYSOSOME-RELATED ORGANELLES ; DENSE-CORE VESICLES ; HILAR MOSSY CELLS ; INTRACELLULAR TRAFFICKING ; DROSOPHILA-MELANOGASTER ; ENDOSOMAL TRAFFICKING ; ZEBRAFISH EMBRYOS ; CHROMAFFIN CELLS ; DENTATE GYRUS ; ESCRT-II
收录类别	SCI
语种	英语
WOS记录号	WOS:000387873300001
内容类型	期刊论文
源URL	[http://ir.ihb.ac.cn/handle/342005/28675]
专题	水生生物研究所_水环境工程研究中心_期刊论文
作者单位	1.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Beijing, Peoples R China 5.Capital Med Univ, Beijing Childrens Hosp, Ctr Med Genet, Beijing, Peoples R China 6.Beijing Inst Brain Disorders, Ctr Alzheimers Dis, Beijing, Peoples R China 7.MOE Key Lab Major Dis Children, Beijing, Peoples R China 8.Beijing Pediat Res Inst, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Wenwen,He, Qiuping,Zhang, Chunxia,et al. BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development[J]. ELIFE,2016,5.
APA	Zhou, Wenwen.,He, Qiuping.,Zhang, Chunxia.,He, Xin.,Cui, Zongbin.,...&Li, Wei.(2016).BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development.ELIFE,5.
MLA	Zhou, Wenwen,et al."BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development".ELIFE 5(2016).