Female-specific effect of the BDNF gene on Alzheimer's disease

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 重大疾病机理的遗传学

	Female-specific effect of the BDNF gene on Alzheimer's disease
	Li GD 1,2; Bi R 1; Wang D 1; Fang YR 3; Li T 4; Zhang C 3; Yao GY[*]1,2,5; Zhang DF 1; Xu M 1,2; Luo RC 1,2
刊名	Neurobiology of Aging
	2017
卷号	53 期号:X 页码:192.e11-192.e19
关键词	Alzheimer’s disease BDNF Gender effect Han Chinese
通讯作者	yaoyg@mail.kiz.ac.cn
英文摘要	Alzheimer's disease (AD) is the most common neurodegenerative disease influenced by genetic and environmental factors. Brain-derived neurotrophic factor (BDNF) plays an important role in the progression of AD, but the genetic association between BDNF and AD remains controversial. In this study, we aimed to explore the potential association between genetic variants in BDNF and AD in Han Chinese and to investigate whether the association is affected by gender. A 3-stage study was conducted to evaluate the genetic association between BDNF and AD. Data mining of the reported expression data, brain-imaging data, and biomarker data in AD patients was also performed to further validate the results. We found a female-specific genetic association of rs6265 with AD and a gender-related messenger RNA expression of BDNF in brain tissues of AD patients. In addition, we observed a clear female-specific risk trend for the effect of rs6265 on AD endophenotypes. Our results clarified the available controversies regarding the role of rs6265 in AD and indicated that BDNF may be a female-specific risk gene for AD.
收录类别	SCI
资助信息	This study was supported by the Strategic Priority Research Program (B) of the Chinese Academy of Sciences (XDB02020003) and the Bureau of Frontier Sciences and Education, Chinese Academy of Sciences (QYZDJ-SSW-SMC005). Data collection and sharing of the ADNI project was funded by the Alzheimer’s Disease Neuroimaging Initiative (ADNI) (National In- stitutes of Health Grant U01 AG024904) and DOD ADNI (Depart- ment of Defense award number W81XWH-12-2-0012).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10865]
专题	昆明动物研究所_重大疾病机理的遗传学昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China 3.Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China 4.The Mental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, China 5.CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China
推荐引用方式 GB/T 7714	Li GD,Bi R,Wang D,et al. Female-specific effect of the BDNF gene on Alzheimer's disease[J]. Neurobiology of Aging,2017,53(X):192.e11-192.e19.
APA	Li GD.,Bi R.,Wang D.,Fang YR.,Li T.,...&Luo RC.(2017).Female-specific effect of the BDNF gene on Alzheimer's disease.Neurobiology of Aging,53(X),192.e11-192.e19.
MLA	Li GD,et al."Female-specific effect of the BDNF gene on Alzheimer's disease".Neurobiology of Aging 53.X(2017):192.e11-192.e19.