Characterization and phylogenetic analysis of Krüppel-like transcription factor (KLF) gene family in tree shrews (Tupaia belangeri chinensis)

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 重大疾病机理的遗传学

	Characterization and phylogenetic analysis of Krüppel-like transcription factor (KLF) gene family in tree shrews (Tupaia belangeri chinensis)
	Shao M 1,2; Ge GZ 1,2; Fan Y 1; Zhao F 1; He BL 3; Chen CS[*]1; Liu WJ 1,4; Xiao J 1,4; Xia HJ 1
刊名	Oncotarget
	2016
卷号	X 期号:X 页码:XX-XX
关键词	KLF KLF5 expression motif tree shrew
通讯作者	chenc@mail.kiz.ac.cn
英文摘要	Krüppel-like factors (KLFs) are a family of zinc finger transcription factors regulating embryonic development and diseases. The phylogenetics of KLFs has not been studied in tree shrews, an animal lineage with a closer relationship to primates than rodents. Here, we identified 17 KLFs from Chinese tree shrew (Tupaia belangeri chinensis). KLF proteins are highly conserved among humans, monkeys, rats, mice and tree shrews compared to zebrafish and chickens. The CtBP binding site, Sin3A binding site and nuclear localization signals are largely conserved between tree shrews and human beings. Tupaia belangeri (Tb) KLF5 contains several conserved post-transcriptional modification motifs. Moreover, the mRNA and protein expression patterns of multiple tbKLFs are tissue-specific . TbKLF5, like hKLF5, significantly promotes NIH3T3 cell proliferation in vitro. These results provide insight for future studies regarding the structure and function of the tbKLF gene family.
收录类别	SCI
资助信息	This study was supported by grants from the National Natural Science Foundation of China (81325016 and 81120108019 to Chen, C., and 31560613 to He, B. L. ).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10796]
专题	昆明动物研究所_重大疾病机理的遗传学昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_肿瘤生物学
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 2.Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China 3.Department of Laboratory Animal Science, Kunming Medical University, Kunming, Yunnan 650500, Chin 4.Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan, China
推荐引用方式 GB/T 7714	Shao M,Ge GZ,Fan Y,et al. Characterization and phylogenetic analysis of Krüppel-like transcription factor (KLF) gene family in tree shrews (Tupaia belangeri chinensis)[J]. Oncotarget,2016,X(X):XX-XX.
APA	Shao M.,Ge GZ.,Fan Y.,Zhao F.,He BL.,...&Xia HJ.(2016).Characterization and phylogenetic analysis of Krüppel-like transcription factor (KLF) gene family in tree shrews (Tupaia belangeri chinensis).Oncotarget,X(X),XX-XX.
MLA	Shao M,et al."Characterization and phylogenetic analysis of Krüppel-like transcription factor (KLF) gene family in tree shrews (Tupaia belangeri chinensis)".Oncotarget X.X(2016):XX-XX.