BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 肿瘤生物学

	BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5
	Qin JY 1,2; Zhou ZM 1; Chen WL 3; Wang CY 1,2,4; Zhang HL 1; Ge GZ 1,5; Shao M 1,5; You DY 6; Fan ZX 6; Xia HJ 1
刊名	NATURE COMMUNICATIONS
	2015
卷号	6 期号:X 页码:e8471
通讯作者	chenc@mail.kiz.ac.cn
合作状况	其它
英文摘要	The transcription factor KLF5 is highly expressed in basal-like breast cancer and promotes breast cancer cell proliferation, survival, migration and tumour growth. Here we show that, in breast cancer cells, KLF5 is stabilized by the deubiquitinase (DUB) BAP1. With a genome-wide siRNA library screen of DUBs, we identify BAP1 as a bona fide KLF5 DUB. BAP1 interacts directly with KLF5 and stabilizes KLF5 via deubiquitination. KLF5 is in the BAP1/HCF-1 complex, and this newly identified complex promotes cell cycle progression partially by inhibiting p27 gene expression. Furthermore, BAP1 knockdown inhibits tumorigenicity and lung metastasis, which can be rescued partially by ectopic expression of KLF5. Collectively, our findings not only identify BAP1 as the DUB for KLF5, but also reveal a critical mechanism that regulates KLF5 expression in breastcancer. Our findings indicate that BAP1 could be a potential therapeutic target for breast and other cancers.
收录类别	SCI
资助信息	This study was supported by the National Key Basic Research Program of China (2013CB910900), the Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406) and the National Natural Science Foundation of China (81120108019, 81325016 and U1132605).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9432]
专题	昆明动物研究所_肿瘤生物学昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Collaborative Innovation Center for Cancer Medicine, Kunming, Yunnan 650223, China. 2.Graduate School of the Chinese Academy of Sciences, Beijing 100039, China 3.Department of Breast Surgery, Breast Cancer Clinical Research Center, Cancer Hospital, Kunming Medical University, Kunming, Yunnan 650031, Chin 4.Department of Pathology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China 5.Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, China 6.Kunming Medical University, Kunming, Yunnan 650031, China
推荐引用方式 GB/T 7714	Qin JY,Zhou ZM,Chen WL,et al. BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5[J]. NATURE COMMUNICATIONS,2015,6(X):e8471.
APA	Qin JY.,Zhou ZM.,Chen WL.,Wang CY.,Zhang HL.,...&Chen CS[*].(2015).BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5.NATURE COMMUNICATIONS,6(X),e8471.
MLA	Qin JY,et al."BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5".NATURE COMMUNICATIONS 6.X(2015):e8471.