Transcriptome Profile Reveals that Pu-Erh Tea Represses the Expression of Vitellogenin Family to Reduce Fat Accumulation in Caenorhabditis elegans

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 脂类代谢与疾病

	Transcriptome Profile Reveals that Pu-Erh Tea Represses the Expression of Vitellogenin Family to Reduce Fat Accumulation in Caenorhabditis elegans
	Xiao RY 1; Hao JJ 2; Liang B[]3; Ding YH 3; Che YY 4; Zou XJ[]5
刊名	Molecules
	2016
卷号	21 期号:X 页码:E1379
关键词	Pu-erh tea water extract (PTE) RNA-Seq fat accumulation vitellogenin (vit) family
通讯作者	xiaojuzou@163.com ; liangb@mail.kiz.ac.cn
合作状况	其它
英文摘要	Background Mitochondrial DNA (mtDNA) is being analyzed by an increasing number of laboratories in order to investigate its potential role as an active marker of tumorigenesis in various types of cancer. Here we question the conclusions drawn in most of these investigations, especially those published in high-rank cancer research journals, under the evidence that a significant number of these medical mtDNA studies are based on obviously flawed sequencing results. Methods and Findings In our analyses, we take a phylogenetic approach and employ thorough database searches, which together have proven successful for detecting erroneous sequences in the fields of human population genetics and forensics. Apart from conceptual problems concerning the interpretation of mtDNA variation in tumorigenesis, in most cases, blocks of seemingly somatic mutations clearly point to contamination or sample mix-up and, therefore, have nothing to do with tumorigenesis. Conclusion The role of mitochondria in tumorigenesis remains unclarified. Our findings of laboratory errors in many contributions would represent only the tip of the iceberg since most published studies do not provide the raw sequence data for inspection, thus hindering a posteriori evaluation of the results. There is no precedent for such a concatenation of errors and misconceptions affecting a whole subfield of medical research.
收录类别	SCI
资助信息	Some strains were provided by the CGC (Caenorhabditis Genetics Center), which is funded by the NIH (National Institutes of Health) Office of Research Infrastructure Programs (P40 OD010440). This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13030600), the National Natural Science Foundation of China (31671230, 31160216, 31171134, U1202223), the Yunnan Natural Science Foundation (2013FA042), the Yunnan Provincial Science and Technology Department (2014HB022 to X.-J.Z.), and the Yunnan Oversea High-level Talents Program (2015HA040 to B.L.).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10592]
专题	昆明动物研究所_脂类代谢与疾病昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_遗传资源与进化国家重点实验室昆明动物研究所_进化与功能基因组学
作者单位	1.Pharmaceutical College, Heilongjiang University of Chinese Medicine, #24Heping Road, Harbin 150040, Chin 2.State Key Laboratory of Genetic Resources and Evolutionary & Functional Genomics, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 3.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 4.Pharmaceutical College, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China 5.Department of Life Science and Biotechnology, Key Laboratory of Special Biological Resource Development and Utilization of University in Yunnan Province, Kunming University, Kunming 650214, China
推荐引用方式 GB/T 7714	Xiao RY,Hao JJ,Liang B[*],et al. Transcriptome Profile Reveals that Pu-Erh Tea Represses the Expression of Vitellogenin Family to Reduce Fat Accumulation in Caenorhabditis elegans[J]. Molecules,2016,21(X):E1379.
APA	Xiao RY,Hao JJ,Liang B[],Ding YH,Che YY,&Zou XJ[].(2016).Transcriptome Profile Reveals that Pu-Erh Tea Represses the Expression of Vitellogenin Family to Reduce Fat Accumulation in Caenorhabditis elegans.Molecules,21(X),E1379.
MLA	Xiao RY,et al."Transcriptome Profile Reveals that Pu-Erh Tea Represses the Expression of Vitellogenin Family to Reduce Fat Accumulation in Caenorhabditis elegans".Molecules 21.X(2016):E1379.