The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 学习记忆的分子神经机制

	The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats
	Yu DF 1,3,4; Zhou H 2,3; Yang Y 1,3,5; Jiang Y 4; Wang TC 4; Lv L 4; Zhou QX 3; Yang YX 3; Dong XX 4; He JF 4
刊名	HORMONES AND BEHAVIOR
	2015
卷号	69 期号:X 页码:106-115
关键词	Hypothyroidism Hyperthyroidism Depression Anxiety Brain-derived neurotrophic factor
通讯作者	lxu@vip.163.com ; talktomaomao@163.com
合作状况	其它
英文摘要	Thyroid hormone disorders have long been linked to depression, but the causal relationship between them remains controversial. To address this question, we established rat models of hypothyroidism using (131)iodine (I-131) and hyperthyroidism using levothyroxine (LT4). Serum free thyroxine (FT4) and triiodothyronine (FT3) significantly decreased in the hypothyroid of rats with single injections of I-131 (5 mCi/kg). These.rats exhibited decreased depression-like behaviors in forced swimming test and sucrose preference tests, as well as decreased anxiety-like behaviors in an elevated plus maze. Diminished levels of brain serotonin (5-HT) and increased levels of hippocampal brain-derived neurotrophic factor (BDNF) were found in the hypothyroid rats compared to the control saline-vehicle administered rats. LT4 treatment reversed the decrease in thyroid hormones and depression-like behaviors. In contrast, hyperthyroidism induced by weekly injections of LT4 (15 mu g/kg) caused a greater than 10-fold increase in serum FT4 and FT3 levels. The hyperthyroid rats exhibited higher anxietyand depression-like behaviors, higher brain 5-HT level, and lower hippocampal BDNF levels than the controls. Treatment with the antidepressant imipramine (15 mg/kg) diminished serum FT4 levels as well as anxietyand depression-like behaviors in the hyperthyroid rats but led to a further increase in brain 5-HT levels, compared with the controls or the hypothyroid rats. Together, our results suggest that hypothyroidism and hyperthyroidism have bidirectional effects on anxiety- and depression-like behaviors in rats, possibly by modulating hippocampal BDNF levels.
收录类别	SCI
资助信息	This work was supported by grants from the973Project (2013CB835103), NSFC-CIHR (81161120536), the Chinese Academy of Sciences (XDB0202002), NSFC (31100786, U1032605 and U1132602), NSFC (81171294), the Science and Technology Program of Yunnan Province (2013GA003 and 2010CD104), and the Natural Scientific Re- search fund (#508 in 2011) of the Chinese Human Resources and Social Security Department.
语种	英语
WOS记录号	WOS:000352118500012
公开日期	2015-04-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/8312]
专题	昆明动物研究所_学习记忆的分子神经机制昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.School of Life Sciences, Yunnan University, Kunming 650091, China 2.School of Life Sciences, University of Science and Technology of China, Hefei, 230026, China 3.Key Laboratoryof Animal Models and Human DiseaseMechanisms, and KIZ/CUHK Joint Laboratory ofBioresources and MolecularResearch inCommon Disease, and Laboratory of Learningand Memory, Kunming Institute of Zoology, Chinese Academy of Science, Kunming 650223, China 4.Department of Nuclear Medicine, First People’s Hospital of Yunnan Province, and Key Laboratory of Medical Imaging, Medical Faculty, Kunming University of Science and Technology, Kunming 650032, China 5.Physiological Department, Kunming Medical University, Kunming 650500, China 6.State Key Laboratory of Phytochemistry and Plant Resources in Southwest China, and Kunming Institute of Botany, Chinese Academy of Science, Kunming 650201, China
推荐引用方式 GB/T 7714	Yu DF,Zhou H,Yang Y,et al. The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats[J]. HORMONES AND BEHAVIOR,2015,69(X):106-115.
APA	Yu DF.,Zhou H.,Yang Y.,Jiang Y.,Wang TC.,...&Mao RR[*].(2015).The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats.HORMONES AND BEHAVIOR,69(X),106-115.
MLA	Yu DF,et al."The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats".HORMONES AND BEHAVIOR 69.X(2015):106-115.