Explorative study on the expression of neuregulin-1 gene in peripheral blood of schizophrenia

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 学习记忆的分子神经机制

	Explorative study on the expression of neuregulin-1 gene in peripheral blood of schizophrenia
	Zhang HX 1,2; Zhao JP[]1; Lv LX[]2; Li WQ 2; Xu L 3; Ouyang X 1; Yuan ZQ 4; Huang JS 1
刊名	NEUROSCIENCE LETTERS
	2008
卷号	438 期号:1 页码:1-5
关键词	schizophrenia neuregulin-1 (NRG-1) mRNA
ISSN号	0304-3940
通讯作者	zhaojingpinghunan@yahoo.com.cn ; lvx928@126.com
合作状况	其它
英文摘要	Neuregulin-1 (Nrg-1)(1) gene has been considered as a schizophrenia susceptibility gene. In order to observe the association of Nrg-1 gene with schizophrenia, the study was designed to investigate the effect of anti-psychotic treatment on the Nrg-1 mRNA expression in peripheral blood lymphocytes of the patients with a diagnosis of schizophrenia. The Nrg-1 mRNA expression in peripheral blood lymphocytes (PBLs) was measured by using semi-quantitative RT-PCR in 31 first-onset schizophrenia patients, 16 sibling controls and 31 no-sibship controls. Results showed that Nrg-1 mRNA expression in PBLs of patients was lower than that in other two control groups (F = 6.722, P = 0.002). However, as follow-up time extended, from the second week, Nrg-1 mRNA expression of PBLs in antipsychotic treated patients gradually increased and has obvious statistical significance compared the efficacy of taking anti-psychotic before and after therapy. These results demonstrated that Nrg-1 gene has association with schizophrenia. It is possible to select Nrg-1 mRNA expression of PBLs in schizophrenia patients as a potential therapeutic marker.
收录类别	SCI
资助信息	The research was supported by National Key Technologies R&DPrograminthe10thFive-year-plangrant2004BA720A22 (Dr. Zhao) from the Ministry of Science and Technology of the People’s Republic of China.
原文出处	20084381.pdf
语种	英语
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/5917]
专题	昆明动物研究所_学习记忆的分子神经机制
作者单位	1.Institute of Mental Health of the Second Xiangya Hospital, Central South University, 139# Renmin Middle Road, Changsha 410011, China 2.Department of Psychiatry of the Second Affiliated Hospital of Xinxiang Medical College, 388# Jianshe Middle Road, Xinxiang 453002, China 3.Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223 Yunnan, China 4.Department of Pathology of Xinxiang Medical College, Xinxiang 453002, China
推荐引用方式 GB/T 7714	Zhang HX,Zhao JP[],Lv LX[],et al. Explorative study on the expression of neuregulin-1 gene in peripheral blood of schizophrenia[J]. NEUROSCIENCE LETTERS,2008,438(1):1-5.
APA	Zhang HX.,Zhao JP[].,Lv LX[].,Li WQ.,Xu L.,...&Huang JS.(2008).Explorative study on the expression of neuregulin-1 gene in peripheral blood of schizophrenia.NEUROSCIENCE LETTERS,438(1),1-5.
MLA	Zhang HX,et al."Explorative study on the expression of neuregulin-1 gene in peripheral blood of schizophrenia".NEUROSCIENCE LETTERS 438.1(2008):1-5.