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题名	食蟹猴产后行为抑郁的自发模型研究
作者	储训训
学位类别	硕士
答辩日期	2013-11
授予单位	中国科学院研究生院
授予地点	北京
导师	胡新天
关键词	产后抑郁症 重性抑郁障碍 生殖特性 产食蟹猴 蜷缩 压力性事件 毛发可的松 母婴关系
其他题名	A natural model of behavioral depression postpartum in adult female cynomolgus monkeys (Macaca fascicularis)
学位专业	神经生物学
中文摘要	根据美国精神病协会制定的精神障碍诊断与统计手册第四版，产后抑郁症（postpartum depression, PPD）被定义为是一类与重性抑郁障碍（major depressive disorders, MDD）相似的临床变体。因为PPD的持续时间短暂（数周至数月）、症状轻微（至少包括两种典型MDD临床表现），对于它的研究远远不及MDD的深入。然而，事实上PPD能够通过破坏产后产妇的身心健康及其与婴儿的交互行为对产妇和新生儿施加不利影响，它所造成的危害较之MDD更为严重。尽快调查出它的病理成因及研究相应的临床治疗手段格外重要。但是，人类产后这一特殊的生理阶段限制了相关研究的开展，造成目前对它尚无满意的临床治疗方法。这一现实凸显出模型研究的重要性。传统的动物模型多以啮齿类动物为载体，然而它们的生殖特性与人类的相差甚远，加上能在其上调查的生物学因素也相对单一，往往不能满足对PPD相关病理成因系统而全面的研究。已知在非人灵长类上存在行为抑郁现象，并且它们在生理、高级脑功能等方面也更接近于人类，因此开发基于PPD的非人灵长类动物模型是可行同时也是十分重要的。 食蟹猴（Macaca fascicularis）是一类重要的猕猴属成员，它们的群体具有高度组织化的社会等级结构。食蟹猴的日常行为丰富，它们的生殖行为不受季节的限制，非常适于作为研究PPD的模型动物使用。在我们的研究中，选择食蟹猴作为研究对象，以蜷缩行为这一在非人灵长类上公认的典型与抑郁相关的行为作为表征行为抑郁的指标，结果我们发现人工群养条件下群体中的部分成年雌性食蟹猴在产后表现出了明显的行为抑郁现象。在排除分娩时失血可能对蜷缩行为产生的影响后，我们初步认定与PPD相似的行为抑郁现象同样存在于食蟹猴群体中。基于这一发现，我们进一步比较了压力性事件、毛发可的松，以及母婴关系这些同PPD相关的生物学因素和我们所观察到的上述产后行为抑郁现象之间的关系。分析的结果显示，压力性事件和毛发可的松的变化并未伴随上述产后行为抑郁现象而出现，但异常的母婴关系与上述产后行为抑郁现象表现出了相关，这一结果进一步证实不良的母婴交互关系确与PPD是相关联的。
英文摘要	According to the DSM-Ⅳ, postpartum depression (PPD) is defined as a modifier similar to major depressive disorders (MDD). Owing to PPD being of short durations (weeks to months) and moderate symptoms (at least two items of mainly clinical manifestations in MDD), this leads to related research for PPD far beneath MDD. While, in fact, PPD can exert negative effects on both mothers and infants through disturbing their interaction processes, therefore it does harm much seriously than MDD. To probe the pathogenesis of PPD and develop effectively clinical interventions for PPD as soon as possible, are considered to being quite important issues. However, both mothers and infants are very susceptible to the postpartum period, by which the relevant research to PPD are restrained, and result to, up to now, no satisfactorily therapeutic methods of PPD being developed. The facts above also highlight the importance of animal models. The rodents are commonly used as model animals in studying PPD, but because there are great gaps on the reproductive characteristic between the rodents and the humans, and the biological factors being explored in the rodent models of PPD are quite simple, these make animal models of PPD based on the rodents unable to competent for systematically studying the ethology of PPD. The behavioral depression phenomena long before was found in the non-human primates, and still their physiological aspects and high brain functions are much more approaching to the humans’ than the rodents’, hence to develop the non-human primate models of PPD can be actually practical and very useful. The cynomolgus monkeys (Macaca fascicularis) are the important member of the Macaca，whose society is of high-organized hierarchy. In addition, their behavioral indexes are very rich, and their reproductive activity is not restricted by seasonal change. In view of this, the advantages above mentioned qualified the cynomolgus monkeys as the very potential tools in study of PPD. In present study, we chose the macaques as the subjects, and employed the typically depressive behavior, the huddle, indicative of behavioral depression postpartum. We found that few of the female adult cynomolgus monkeys in breeding group demonstrated behavioral depression postpartum. On the other hand, the mother monkeys in deliver are always companied by the loss of blood, which are suspected to be able to induce the occurrence of huddling. After removing this confounding factor, we preliminarily confirmed that the behavioral depression postpartum similar to PPD exists in the non-human primates. Based on the finding, we further analyzed the relationship of stressful events、cortisol in hair, and maternal relationship with the above PPD-related behavior phenomena in female adult cynomolgus monkeys. The results revealed that there were no differences in both stressful events and hair cortisol between behavioral depression postpartum group and non-behavioral depression postpartum group we observed, as abnormal maternal relationship emerged with the behavioral depression postpartum mentioned above，which further proved poor maternal relationship linked to PPD.
语种	中文
公开日期	2013-12-25
内容类型	学位论文
源URL	[http://159.226.149.42:8088/handle/152453/7749]
专题	昆明动物研究所_神经系统编码
推荐引用方式 GB/T 7714	储训训. 食蟹猴产后行为抑郁的自发模型研究[D]. 北京. 中国科学院研究生院. 2013.

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