Pre-conditioned place preference treatment of chloral hydrate interrupts the rewarding effect of morphine

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 神经系统编码

	Pre-conditioned place preference treatment of chloral hydrate interrupts the rewarding effect of morphine
	Sun YM 1,2; Zong W 1; Zhou MR 3; Ma YY 1; Wang JH[*]1
刊名	PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
	2015
卷号	135 期号:X 页码:60-63
关键词	Morphine Chloral hydrate Rewarding effect Conditioned place preference
通讯作者	wangjh@mail.kiz.ac.cn
合作状况	其它
英文摘要	The medical use of morphine as a pain killer is hindered by its side effects including dependence and further addiction. As the prototypical mu receptor agonist, morphine's rewarding effect can be measured by conditioned place preference (CPP) paradigms in animals. Chloral hydrate is a clinical sedative. Using a morphine CPP paradigm that mainly contains somatosensory cues, we found that pre-CPP treatment in rats using chloral hydrate for 6 consecutive days could disrupt the establishment of CPP in a U shape. Chloral hydrate had no effect on the body weight of rats. Our results indicate that prior treatment with chloral hydrate can interrupt the rewarding effect of morphine.
收录类别	SCI
资助信息	This study was supported by the 973 program (2012CB825500, 2011CB707800), NSFC (31271168, 91132307) and the NSFC Chinese– Finnishjointproject813111172. Theauthors thankProfessor Dr.Sabine Spijker for her critical reading of the manuscript and her valuable suggestions.
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9319]
专题	昆明动物研究所_神经系统编码昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_认知障碍病理学
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, PR China 2.Department of Molecular and Cellular Neurobiology, Center for Neurogenomics & Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, Netherlands 3.School of Pharmacy, Fu Dan University, Shanghai, PR China
推荐引用方式 GB/T 7714	Sun YM,Zong W,Zhou MR,et al. Pre-conditioned place preference treatment of chloral hydrate interrupts the rewarding effect of morphine[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2015,135(X):60-63.
APA	Sun YM,Zong W,Zhou MR,Ma YY,&Wang JH[*].(2015).Pre-conditioned place preference treatment of chloral hydrate interrupts the rewarding effect of morphine.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,135(X),60-63.
MLA	Sun YM,et al."Pre-conditioned place preference treatment of chloral hydrate interrupts the rewarding effect of morphine".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 135.X(2015):60-63.