Morphine and propranolol co-administration impair consolidation of Y-maze spatial recognition memory

	Morphine and propranolol co-administration impair consolidation of Y-maze spatial recognition memory
	Zhang J 1,2,3; He J 1,2,3; Chen YM 1,2,3; Wang JH[]1,2,3; Ma YY[]1,2,4
刊名	BRAIN RESEARCH
	2008
卷号	1230 期号:X 页码:150-157
关键词	beta-adrenoceptor mice Cathelicidin Elapid snake Molecular cloning Phylogenetic analysis
ISSN号	0006-8993
通讯作者	wangjh@mail.kiz.ac.cn ; yuanma07l6@vip.sina.com
合作状况	其它
英文摘要	In the present study, the interaction between morphine and the beta-adrenergic receptor antagonist, propranolol (PROP), in memory consolidation was investigated in a two-trial recognition Y-maze task. Four sets of Y-maze experiments were carried out in mice, with 2 and 4 h inter-trial intervals (ITI) and all drugs administered immediately after the training trials. In the first and second. sets of experiments, post-training administration of morphine (0.25 and 2.5 mg/kg) or PROP (2, 10 and 20 mg/kg) alone did not impair memory consolidation after a 2 h ITI. However, in the third and fourth sets of experiments, co-administration of these ineffective doses of morphine (0.25 and 2.5 mg/kg) and PROP (2, 10 and 20 mg/kg) disrupted memory consolidation after a 2 h ITI. Moreover, the relatively higher dose of morphine (2.5 mg/kg) plus the relatively higher doses of PROP (10 and 20 mg/kg) disrupted memory consolidation to a greater extent after a 2 h ITI. Locomotor activity was not affected by any of the drug treatments. Our data shows that morphine and PROP co-administration disrupts the consolidation of spatial recognition memory, suggesting that inactivation of the beta-adrenergic system may contribute to morphine-induced impairment of memory.
学科主题	Neurosciences
收录类别	SCI
资助信息	This study was supported by the National Science Foundation of China (NSFC 30470553, 30770700 and 30530270), the 973 program (2005CB522803, 2007CB947703), the 863 program (O7013810), the Chinese- FinnishInternationalCollaborationProject-Neuro(30621130076), the Program of CASC (KSCX1-YW-R-33) and the National Key Technologies R&D Program.
语种	英语
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/5465]
专题	昆明动物研究所_认知障碍病理学昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_神经系统编码昆明动物研究所_中国科学院昆明灵长类研究中心
作者单位	1.Laboratory of Primate Neuroscience Research and Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, PR China 2.Kunming Primate Center, Chinese Academy of Sciences, Kunming, Yunnan, PR China 3.Graduate School of Chinese Academy of Sciences, Beijing, PR China 4.Kunming Biomed International, Kunming, Yunnan, PR China
推荐引用方式 GB/T 7714	Zhang J,He J,Chen YM,et al. Morphine and propranolol co-administration impair consolidation of Y-maze spatial recognition memory[J]. BRAIN RESEARCH,2008,1230(X):150-157.
APA	Zhang J,He J,Chen YM,Wang JH[],&Ma YY[].(2008).Morphine and propranolol co-administration impair consolidation of Y-maze spatial recognition memory.BRAIN RESEARCH,1230(X),150-157.
MLA	Zhang J,et al."Morphine and propranolol co-administration impair consolidation of Y-maze spatial recognition memory".BRAIN RESEARCH 1230.X(2008):150-157.