Convergent Evolution of Rumen Microbiomes in High-Altitude Mammals

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 进化与功能基因组学

	Convergent Evolution of Rumen Microbiomes in High-Altitude Mammals
	Zhang ZG 1; Xu DM 1,4; Zhou X 1; Wang WW 3; Qiu Q 3; Huang XD 3; Zhou JW 3; Long RJ[]3; Wang L 3; Zhao FQ[]2
刊名	Current Biology
	2016
卷号	26 期号:14 页码:1873-1879
通讯作者	longrj@lzu.edu.cn ; zhfq@biols.ac.cn ; ship@mail.kiz.ac.cn
英文摘要	Studies of genetic adaptation, a central focus of evolutionary biology, most often focus on the host's genome and only rarely on its co-evolved microbiome. The Qinghai-Tibetan Plateau (QTP) offers one of the most extreme environments for the survival of human and other mammalian species. Yaks (Bos grunniens) and Tibetan sheep (T-sheep) (Ovis aries) have adaptations for living in this harsh high-altitude environment, where nomadic Tibetan people keep them primarily for food and livelihood [1]. Adaptive evolution affects energy-metabolism-related genes in a way that helps these ruminants live at high altitude [2, 3]. Herein, we report convergent evolution of rumen microbiomes for energy harvesting persistence in two typical high-altitude ruminants, yaks and T-sheep. Both ruminants yield significantly lower levels of methane and higher yields of volatile fatty acids (VFAs) than their low-altitude relatives, cattle (Bos taurus) and ordinary sheep (Ovis aries). Ultra-deep metagenomic sequencing reveals significant enrichment in VFA-yielding pathways of rumen microbial genes in high-altitude ruminants, whereas methanogenesis pathways show enrichment in the cattle metagenome. Analyses of RNA transcriptomes reveal significant upregulation in 36 genes associated with VFA transport and absorption in the ruminal epithelium of high-altitude ruminants. Our study provides novel insights into the contributions of microbiomes to adaptive evolution in mammals and sheds light on the biological control of greenhouse gas emissions from livestock enteric fermentation.
收录类别	SCI
资助信息	The project was supported by the ‘‘Strategic Priority Research Program’’ of the Chinese Academy of Sciences (grant no. XDB13020400), the National Key Basic Research Program of China (973 Program) (2013CB835203), Yunnan province, the High-end Scientific and Technological Talents program (2013HA020), and the National Natural Science Foundation of China (31321002, 31325013, 31471201, and 31170378).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10104]
专题	昆明动物研究所_进化与功能基因组学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Laboratory of Evolutionary and Functional Genomics, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 2.Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China 3.State Key Laboratory of Grassland Agro-ecosystems and International Center for Tibetan Plateau Ecosystem Management of the School of Life Science, Lanzhou University, Lanzhou 730000, Gansu, China 4.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650204, Yunnan, China 5.IZ-SU Joint Laboratory of Animal Model and Drug Development, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China
推荐引用方式 GB/T 7714	Zhang ZG,Xu DM,Zhou X,et al. Convergent Evolution of Rumen Microbiomes in High-Altitude Mammals[J]. Current Biology,2016,26(14):1873-1879.
APA	Zhang ZG.,Xu DM.,Zhou X.,Wang WW.,Qiu Q.,...&Wang JF.(2016).Convergent Evolution of Rumen Microbiomes in High-Altitude Mammals.Current Biology,26(14),1873-1879.
MLA	Zhang ZG,et al."Convergent Evolution of Rumen Microbiomes in High-Altitude Mammals".Current Biology 26.14(2016):1873-1879.