Duodenal Ferroportin Is Up-Regulated in Patients with Chronic Hepatitis C

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	Duodenal Ferroportin Is Up-Regulated in Patients with Chronic Hepatitis C
	Ma LQ 1; Zou T 2; Yuan YP 1; Lv JJ 1; Dong XQ 1; Yang G 1; Zhu YZ 1; Luo J 1; Zhang ZG[]3; Yang JF[]2
刊名	PLOS ONE
	2014
卷号	9 期号:10 页码:e110658
通讯作者	zhzhg2007@gmail.com ; yangjiefu2011@126.com
英文摘要	Hepatitis C virus (HCV) infection is a leading cause of liver-related mortality. Chronic hepatitis C (CHC) is frequently associated with disturbances in iron homeostasis, with serum iron and hepatic iron stores being elevated. Accumulating evidence indicates that chronic HCV infection suppresses expression of hepatic hepcidin, a key mediator of iron homeostasis, leading to iron overload conditions. Since hepcidin mediates degradation of ferroportin, a basolateral transporter involved in the release of iron from cells, diminished hepcidin expression probably leads to up-regulation of ferroportin-1 (Fpn1) in patients with CHC. In this study, we determined the protein levels of duodenal Fpn1, and found that its expression was significantly up-regulated in patients with CHC. The expression of duodenal Fpn1 is negatively correlated with mRNA levels of hepcidin, and positively correlated with serum iron parameters. Although iron is a critical factor for growth of a variety of pathogenic bacteria, our results suggest that iron overload in blood does not increase the infection rate of bacteria in patients with CHC.
收录类别	SCI
资助信息	The authors acknowledge funding from a grant (2010ZC126) from Yunnan Department of Science and Technology (to LM), and a grant (81170171) from the National Natural Science Foundation of China (to JY)
语种	英语
WOS记录号	WOS:000343942100080
公开日期	2014-12-05
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/8191]
专题	昆明动物研究所_进化与功能基因组学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.Department of Digestive Diseases, The First Affiliated Hospital, Kunming Medical University, Kunming, Yunnan, China 2.Department of Cardiology, Beijing Hospital, Ministry of Health, Beijing, China 3.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, CAS, Kunming, Yunnan, China
推荐引用方式 GB/T 7714	Ma LQ,Zou T,Yuan YP,et al. Duodenal Ferroportin Is Up-Regulated in Patients with Chronic Hepatitis C[J]. PLOS ONE,2014,9(10):e110658.
APA	Ma LQ.,Zou T.,Yuan YP.,Lv JJ.,Dong XQ.,...&Yang JF[*].(2014).Duodenal Ferroportin Is Up-Regulated in Patients with Chronic Hepatitis C.PLOS ONE,9(10),e110658.
MLA	Ma LQ,et al."Duodenal Ferroportin Is Up-Regulated in Patients with Chronic Hepatitis C".PLOS ONE 9.10(2014):e110658.