Spatial heterogeneity and co-occurrence patterns of human mucosal-associated intestinal microbiota

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 进化与功能基因组学

	Spatial heterogeneity and co-occurrence patterns of human mucosal-associated intestinal microbiota
	Zhang ZG 1; Geng JW 2; Tang XD 2; Fan H 2; Xu JC 3; Wen XJ 4; Ma ZS[]1; Shi P[]1
刊名	ISME JOURNAL
	2014
卷号	8 期号:4 页码:881-893
关键词	ecological model intestine microbiota systems biology spatial scaling
通讯作者	ma@vandals.uidaho.edu ; ship@mail.kiz.ac.cn
合作状况	其它
英文摘要	Human gut microbiota shows high inter-subject variations, but the actual spatial distribution and co-occurrence patterns of gut mucosa microbiota that occur within a healthy human instestinal tract remain poorly understood. In this study, we illustrated a model of this mucosa bacterial communities' biogeography, based on the largest data set so far, obtained via 454-pyrosequencing of bacterial 16S rDNAs associated with 77 matched biopsy tissue samples taken from terminal ileum, ileocecal valve, ascending colon, transverse colon, descending colon, sigmoid colon and rectum of 11 healthy adult subjects. Borrowing from macro-ecology, we used both Taylor's power law analysis and phylogeny-based beta-diversity metrics to uncover a highly heterogeneous distribution pattern of mucosa microbial inhabitants along the length of the intestinal tract. We then developed a spatial dispersion model with an R-squared value greater than 0.950 to map out the gut mucosa-associated flora's non-linear spatial distribution pattern for 51.60% of the 188 most abundant gut bacterial species. Furthermore, spatial co-occurring network analysis of mucosa microbial inhabitants together with occupancy (that is habitat generalists, specialists and opportunist) analyses implies that ecological relationships (both oppositional and symbiotic) between mucosa microbial inhabitants may be important contributors to the observed spatial heterogeneity of mucosa microbiota along the human intestine and may even potentially be associated with mutual cooperation within and functional stability of the gut ecosystem.
收录类别	SCI
资助信息	This research was supported by the following grants: National Natural Science Founda- tion of China (Grant No. 31100916 to ZZ and Grant No. 61175071 to ZM); Natural Science Foundation of Yunnan Province of China (Grant No. 2011FA035 to PS and Grant No. 2010CD191 to JG); ‘A Hundred Talent Program’ from Chinese Academy of Sciences to PS and ZM, respectively; the three grants to ZM (that is, ‘Top Talents Program in Science and Technology’ from Yunnan Province, ‘Top Talents from Overseas’ from Yunan Province and ‘Inno- vative Research Initiative of the Synergy between the Natural and Computational Evolutions’ of CAS-Yunan Province). Sequences were deposited in the NCBI Sequence Read Archive (accession number SRA052611).
WOS记录号	WOS:000333189700013
公开日期	2014-06-03
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7858]
专题	昆明动物研究所_进化与功能基因组学昆明动物研究所_遗传资源与进化国家重点实验室昆明动物研究所_计算生物与生物信息学
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Kunming, China 3.Center for Computational Mathematics and Applications, Department of Mathematics, Pennsylvania State University, University Park, PA, USA 4.College of Forestry, South China Agricultural University, Guangzhou, China
推荐引用方式 GB/T 7714	Zhang ZG,Geng JW,Tang XD,et al. Spatial heterogeneity and co-occurrence patterns of human mucosal-associated intestinal microbiota[J]. ISME JOURNAL,2014,8(4):881-893.
APA	Zhang ZG.,Geng JW.,Tang XD.,Fan H.,Xu JC.,...&Shi P[*].(2014).Spatial heterogeneity and co-occurrence patterns of human mucosal-associated intestinal microbiota.ISME JOURNAL,8(4),881-893.
MLA	Zhang ZG,et al."Spatial heterogeneity and co-occurrence patterns of human mucosal-associated intestinal microbiota".ISME JOURNAL 8.4(2014):881-893.