Tigliane-Type Diterpenoid Glycosides from Euphorbia fischeriana

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 分子免疫药理学

	Tigliane-Type Diterpenoid Glycosides from Euphorbia fischeriana
	Pan LL 1,3; Fang PL 1; Yang LM 2; Chen CX 1; Zheng YT 2; Li CT 3; Hao XJ 1; Liu HY[*]1; Zhang XJ 2; Ni W 1
刊名	JOURNAL OF NATURAL PRODUCTS
	2011
卷号	74 期号:6 页码:1508-1512
通讯作者	haiyangliu@mail.kib.ac.cn
合作状况	其它
英文摘要	Investigation of whole plants of Euphorbia fischeriana afforded three new tigliane-diterpenoid glycosides, fischerosides A-C (1-3), together with 11 known diterpenoids. Fischerosides A-C (1-3) are the first tigliane-type diterpenoid glucosides. Their structures were determined by a combination of 1D and 2D NMR, MS, and acid hydrolysis. Inhibitory activity against HIV-1 was assessed for compounds 1-5. The new compound 3 showed an EC(50) value of 0.02 mu M and a therapeutic index (TI) of 17.50, while prostratin (4) and 12-deoxyphorbol-13,20-diacetate (5) showed significantly greater anti-HIV-1 activity.
收录类别	SCI
资助信息	This work was supported by the Young Academic and Technical Leader Raising Foundation of Yunnan Province (2008PY066) and funds (P2010-ZZ02) from the State Key Laboratory of Phytochemistry and Plant Resources in West China.
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10429]
专题	昆明动物研究所_分子免疫药理学昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People’s Republic of China 2.Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, People’s Republic of China 3.College of Chinese Medicinal Material, Jilin Agricultural University, Changchun 130118, People’s Republic of China
推荐引用方式 GB/T 7714	Pan LL,Fang PL,Yang LM,et al. Tigliane-Type Diterpenoid Glycosides from Euphorbia fischeriana[J]. JOURNAL OF NATURAL PRODUCTS,2011,74(6):1508-1512.
APA	Pan LL.,Fang PL.,Yang LM.,Chen CX.,Zheng YT.,...&Li L.(2011).Tigliane-Type Diterpenoid Glycosides from Euphorbia fischeriana.JOURNAL OF NATURAL PRODUCTS,74(6),1508-1512.
MLA	Pan LL,et al."Tigliane-Type Diterpenoid Glycosides from Euphorbia fischeriana".JOURNAL OF NATURAL PRODUCTS 74.6(2011):1508-1512.