The depolymerized fucosylated chondroitin sulfate from sea cucumber potently inhibits HIV replication via interfering with virus entry

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 分子免疫药理学

	The depolymerized fucosylated chondroitin sulfate from sea cucumber potently inhibits HIV replication via interfering with virus entry
	Huang N 1,4; Wu MY 2; Zheng CB 3; Zhu L 1; Zhao JH[]2; Zheng YT[]1
刊名	CARBOHYDRATE RESEARCH
	2013
卷号	380 期号:X 页码:64-69
关键词	Fucosylated chondroitin sulfate HIV-1 Anti-HIV agent HIV entry
通讯作者	zhao.jinhua@yahoo.com ; zhengyt@mail.kiz.ac.cn
合作状况	其它
英文摘要	Fucosylated chondroitin sulfate (FuCS-1) is a nontoxic and water-soluble depolymerized glycosaminoglycan obtained from the sea cucumber Thelenota ananas. Anti-HIV activities of FuCS-1 were evaluated in the present study. FuCS-1 was effective in blocking laboratory strain HIV-1(IIIB) entry and replication (4.26 mu g/mL and 0.73 mu g/mL, respectively), and inhibiting infection by clinic isolate HIV-1(KM018) and HIV-1(TC-2) (23.75 mu g/mL and 31.86 mu g/mL, respectively) as well as suppressing HIV-1 drug-resistant virus. It also inhibited HIV-2(ROD) and HIV-2(CBL-20) replication (100 mu g/mL). Notably, FuCS-1 showed highly effective antiviral activity against T-20-resistant strains (EC50 values ranging from 0.76 mu g/mL to 1.13 mu g/mL). Further studies indicated that FuCS-1 can potently bind the recombinant HIV-1 gp120 protein, but no inhibition of recombinant HIV-1 reverse transcriptase was observed. In conclusion, FuCS-1 inhibited several strains of HIV-1 replication with different potencies. These results suggest that FuCS-1 may possess great potential to be further developed as novel HIV-1 entry inhibitor for treatment of HIV/AIDS patients, particularly for those infected by T-20-resistant variants.
收录类别	SCI
资助信息	This work was supported in part by grants from the National Natural Science Foundation of China (81102483, 81001462 and 81102372), 973 Program (2009CB522306) and the Key Scientific and Technological Program of China (2009ZX09501-029, 2012ZX10001-006, 2012ZX10001-007 and 2012ZX09103-101- 022) and Yunnan (2007BC006, 2010GA001 and 2012BC011).
语种	英语
WOS记录号	WOS:000325167400010
公开日期	2014-10-22
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/8125]
专题	昆明动物研究所_分子免疫药理学昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Science & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650204, China 3.School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China 4.School of Basic Medical, Kunming Medical University, Kunming, Yunnan 650500, China
推荐引用方式 GB/T 7714	Huang N,Wu MY,Zheng CB,et al. The depolymerized fucosylated chondroitin sulfate from sea cucumber potently inhibits HIV replication via interfering with virus entry[J]. CARBOHYDRATE RESEARCH,2013,380(X):64-69.
APA	Huang N,Wu MY,Zheng CB,Zhu L,Zhao JH[],&Zheng YT[].(2013).The depolymerized fucosylated chondroitin sulfate from sea cucumber potently inhibits HIV replication via interfering with virus entry.CARBOHYDRATE RESEARCH,380(X),64-69.
MLA	Huang N,et al."The depolymerized fucosylated chondroitin sulfate from sea cucumber potently inhibits HIV replication via interfering with virus entry".CARBOHYDRATE RESEARCH 380.X(2013):64-69.