HIV Infection in Gastric Epithelial Cells

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 分子免疫药理学

	HIV Infection in Gastric Epithelial Cells
	Liu R 1; Huang L 2; Li JY 1; Zhou XZ 2; Zhang HY 3; Zhang T 1; Lei YL 1; Wang K 1; Xie N 1; Zheng YT 4
刊名	JOURNAL OF INFECTIOUS DISEASES
	2013
卷号	208 期号:8 页码:1221-1230
关键词	AIDS epithelial cells gastric mucosa HIV
通讯作者	hcanhua@hotmail.com
英文摘要	Many chronic human immunodeficiency virus (HIV) patients suffer from gastric complaints, including gastric tuberculosis and coinfection of other pathogens. Recent work has demonstrated that a variety of nonimmune cells can act as viral reservoirs, even at the early stage of HIV infection. In this study, we detect HIV viral particles, proteins, and nucleic acids in gastric epithelial cells using clinical samples. These observations are further supported by a simian immunodeficiency virus-infected macaque model. Further, the number of HIV-infected gastric epithelial cells is positively associated with blood viral load, and is negatively correlated with CD4 lymphocyte cell counts. We also demonstrate that HIV infection is accompanied by severe inflammatory response in gastric mucosa. Additionally, HIV infection activates signal transducer and activator of transcription 3 and RelA, and enhances the production of interleukin 6 and tumor necrosis factor a in gastric epithelial cells. The present data suggest that the gastric epithelial cells are natural targets of HIV infection, and HIV infection in epithelial cells contributes to HIV-induced gastric mucosal inflammation.
收录类别	SCI
资助信息	This work was supported by grants from the Nation- al 973 Basic Research Program of China (2013CB911300, 2012CB518900), the National Science and Technology Major Project (2011ZX09302-001-01 and 2012ZX09501001-003), and the Natural Science Foundation of China (81225015, 81072022, 81172173, 30771897).
语种	英语
WOS记录号	WOS:000324832800005
公开日期	2014-10-16
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/8076]
专题	昆明动物研究所_分子免疫药理学昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 2.The 302 Hospital of PLA, Beijing 3.The School of Medicine, Yangtze University, Shashi, Hubei 4.Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, P. R. China 5.Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia 6.Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago
推荐引用方式 GB/T 7714	Liu R,Huang L,Li JY,et al. HIV Infection in Gastric Epithelial Cells[J]. JOURNAL OF INFECTIOUS DISEASES,2013,208(8):1221-1230.
APA	Liu R.,Huang L.,Li JY.,Zhou XZ.,Zhang HY.,...&Wei YQ.(2013).HIV Infection in Gastric Epithelial Cells.JOURNAL OF INFECTIOUS DISEASES,208(8),1221-1230.
MLA	Liu R,et al."HIV Infection in Gastric Epithelial Cells".JOURNAL OF INFECTIOUS DISEASES 208.8(2013):1221-1230.