Repeated functional convergent effects of Na(V)1.7 on acid insensitivity in hibernating mammals | |
Liu Z1,2; Wang W1,2; Huang JF1; Jiang XL1; Murphy RW1,4; Shi P[*]1; Zhang TZ3; Li GH1; He K1 | |
刊名 | PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES |
2014 | |
卷号 | 281期号:1776页码:e20132950 |
关键词 | SCN9A adaptation convergent evolution acid insensitivity |
通讯作者 | ship@mail.kiz.ac.cn |
合作状况 | 其它 |
英文摘要 | Hibernating mammals need to be insensitive to acid in order to cope with conditions of high CO2; however, the molecular basis of acid tolerance remains largely unknown. The African naked mole-rat (Heterocephalus glaber) and hibernating mammals share similar environments and physiological features. In the naked mole-rat, acid insensitivity has been shown to be conferred by the functional motif of the sodium ion channel Na(V)1.7. There is now an opportunity to evaluate acid insensitivity in other taxa. In this study, we tested for functional convergence of Na(V)1.7 in 71 species of mammals, including 22 species that hibernate. Our analyses revealed a functional convergence of amino acid sequences, which occurred at least six times independently in mammals that hibernate. Evolutionary analyses determined that the convergence results from both parallel and divergent evolution of residues in the functional motif. Our findings not only identify the functional molecules responsible for acid insensitivity in hibernating mammals, but also open new avenues to elucidate the molecular underpinnings of acid insensitivity in mammals. |
收录类别 | SCI |
资助信息 | This work was supported by a start-up fund of the ‘Hundreds-Talent Program’ from the Chinese Academy of Sciences and by grants from the National Natural Science Foundation of China (30930015, 31325013) to P.S. Manuscript preparation was sup- ported by a fellowship for Senior International Scientists and, in part, by a Visiting Professorship for Senior International Scientists from the Chinese Academy of Sciences and the Natural Sciences and Engineering Research Council of Canada (Discovery grant no. 3148). |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://159.226.149.26:8080/handle/152453/9399] |
专题 | 昆明动物研究所_分子进化基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_结构生物信息学 昆明动物研究所_进化与功能基因组学 昆明动物研究所_兽类生态与进化 |
作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.University of the Chinese Academy of Sciences, Beijing 100039, China 3.Key Laboratory of Adaptation and Evolution of Plateau Biota, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, China 4.Centre for Biodiversity and Conservation Biology, Royal Ontario Museum, Toronto, Canada M5S 2C6 |
推荐引用方式 GB/T 7714 | Liu Z,Wang W,Huang JF,et al. Repeated functional convergent effects of Na(V)1.7 on acid insensitivity in hibernating mammals[J]. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES,2014,281(1776):e20132950. |
APA | Liu Z.,Wang W.,Huang JF.,Jiang XL.,Murphy RW.,...&He K.(2014).Repeated functional convergent effects of Na(V)1.7 on acid insensitivity in hibernating mammals.PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES,281(1776),e20132950. |
MLA | Liu Z,et al."Repeated functional convergent effects of Na(V)1.7 on acid insensitivity in hibernating mammals".PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES 281.1776(2014):e20132950. |
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