Genetic Convergence in the Adaptation of Dogs and Humans to the High-Altitude Environment of the Tibetan Plateau

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 分子进化基因组学

	Genetic Convergence in the Adaptation of Dogs and Humans to the High-Altitude Environment of the Tibetan Plateau
	Wang GD 1; Fan RX 2; Zhai WW 3,4; Liu F 1; Wang L 2; Zhong L 2; Wu H 2; Yang HC 1,5; Wu SF 1; Zhu CL 1
刊名	GENOME BIOLOGY AND EVOLUTION
	2014
卷号	6 期号:8 页码:2122-2128
关键词	EPAS1 Tibetan village dog convergence high-altitude adaptation
通讯作者	zhangyp@mail.kiz.ac.cn
合作状况	其它
英文摘要	The high-altitude hypoxic environment represents one of the most extreme challenges for mammals. Previous studies of humans on the Tibetan plateau and in the Andes Mountains have identified statistical signatures of selection in different sets of loci. Here, we first measured the hemoglobin levels in village dogs from Tibet and those from Chinese lowlands. We found that the hemoglobin levels are very similar between the two groups, suggesting that Tibetan dogs might share similar adaptive strategies as the Tibetan people. Through a whole-genome sequencing approach, we have identified EPAS1 and HBB as candidate genes for the hypoxic adaptation on the Tibetan plateau. The population genetic analysis shows a significant convergence between humans and dogs in Tibet. The similarities in the sets of loci that exhibit putative signatures of selection and the hemoglobin levels between humans and dogs of the same environment, but not between human populations in different regions, suggests an extraordinary landscape of convergent evolution between human beings and their best friend on the Tibetan plateau.
收录类别	SCI
资助信息	This work was supported by grants from the National Natural Science Foundation of China (91231108), the 973 program (2013CB835200), and the Key Research Program of the Chinese Academy of Sciences (KJZD-EW-L07).
语种	英语
WOS记录号	WOS:000342976600018
公开日期	2014-09-12
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/8001]
专题	昆明动物研究所_分子进化基因组学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming, China 3.Center for Computational Biology and Laboratory of Disease Genomics and Individualized Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China 4.Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 5.Department of Molecular and Cell Biology, School of Life Sciences, University of Science and Technology of China, Hefei, China 6.Key Laboratory for High Altitude Medicine of Ministry of Chinese Education and Research Center for High Altitude Medicine, Qinghai University, Xining, China 7.Department of Ecology and Evolution, University of Chicago
推荐引用方式 GB/T 7714	Wang GD,Fan RX,Zhai WW,et al. Genetic Convergence in the Adaptation of Dogs and Humans to the High-Altitude Environment of the Tibetan Plateau[J]. GENOME BIOLOGY AND EVOLUTION,2014,6(8):2122-2128.
APA	Wang GD.,Fan RX.,Zhai WW.,Liu F.,Wang L.,...&Zhang YP[*].(2014).Genetic Convergence in the Adaptation of Dogs and Humans to the High-Altitude Environment of the Tibetan Plateau.GENOME BIOLOGY AND EVOLUTION,6(8),2122-2128.
MLA	Wang GD,et al."Genetic Convergence in the Adaptation of Dogs and Humans to the High-Altitude Environment of the Tibetan Plateau".GENOME BIOLOGY AND EVOLUTION 6.8(2014):2122-2128.