Genome-Wide Scans for Candidate Genes Involved in the Aquatic Adaptation of Dolphins

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 分子进化基因组学

	Genome-Wide Scans for Candidate Genes Involved in the Aquatic Adaptation of Dolphins
	Sun YB 1,2; Zhou WP 1,2,3; Liu HQ 1,2,4; Irwin DM 1,5,6; Shen YY[]1,7; Zhang YP[]1,2
刊名	GENOME BIOLOGY AND EVOLUTION
	2013
卷号	5 期号:1 页码:130-139
关键词	Tursiops truncates aquatic adaptation positive selection branch-site model
通讯作者	shen_yongyi@yahoo.com.cn ; zhangyp@mail.kiz.ac.cn
合作状况	其它
英文摘要	Since their divergence from the terrestrial artiodactyls, cetaceans have fully adapted to an aquatic lifestyle, which represents one of the most dramatic transformations in mammalian evolutionary history. Numerous morphological and physiological characters of cetaceans have been acquired in response to this drastic habitat transition, such as thickened blubber, echolocation, and ability to hold their breath for a long period of time. However, knowledge about the molecular basis underlying these adaptations is still limited. The sequence of the genome of Tursiops truncates provides an opportunity for a comparative genomic analyses to examine the molecular adaptation of this species. Here, we constructed 11,838 high-quality orthologous gene alignments culled from the dolphin and four other terrestrial mammalian genomes and screened for positive selection occurring in the dolphin lineage. In total, 368 (3.1%) of the genes were identified as having undergone positive selection by the branch-site model. Functional characterization of these genes showed that they are significantly enriched in the categories of lipid transport and localization, ATPase activity, sense perception of sound, and muscle contraction, areas that are potentially related to cetacean adaptations. In contrast, we did not find a similar pattern in the cow, a closely related species. We resequenced some of the positively selected sites (PSSs), within the positively selected genes, and showed that most of our identified PSSs (50/52) could be replicated. The results from this study should have important implications for our understanding of cetacean evolution and their adaptations to the aquatic environment.
收录类别	SCI
资助信息	This work was supported by grants from the National Natural Science Foundation of China (2007CB411600, 2008GA001) and the Bureau of Science and Technology of Yunnan Province (31061160189).
语种	英语
WOS记录号	WOS:000314778600011
公开日期	2013-03-14
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7274]
专题	昆明动物研究所_分子进化基因组学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming, China 3.Department of Molecular and Cell Biology, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China 4.Graduate School of the Chinese Academy of Sciences, Beijing, China 5.Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada 6.Banting and Best Diabetes Centre, University of Toronto, Ontario, Canada 7.School of Life Sciences, Xiamen University, Xiamen, China
推荐引用方式 GB/T 7714	Sun YB,Zhou WP,Liu HQ,et al. Genome-Wide Scans for Candidate Genes Involved in the Aquatic Adaptation of Dolphins[J]. GENOME BIOLOGY AND EVOLUTION,2013,5(1):130-139.
APA	Sun YB,Zhou WP,Liu HQ,Irwin DM,Shen YY[],&Zhang YP[].(2013).Genome-Wide Scans for Candidate Genes Involved in the Aquatic Adaptation of Dolphins.GENOME BIOLOGY AND EVOLUTION,5(1),130-139.
MLA	Sun YB,et al."Genome-Wide Scans for Candidate Genes Involved in the Aquatic Adaptation of Dolphins".GENOME BIOLOGY AND EVOLUTION 5.1(2013):130-139.