Evaluating the Roles of Energetic Functional Constraints on Teleost Mitochondrial-Encoded Protein Evolution

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 分子进化基因组学

	Evaluating the Roles of Energetic Functional Constraints on Teleost Mitochondrial-Encoded Protein Evolution
	Sun YB 1,2; Shen YY 1,2; Irwin DM 3,4; Zhang YP[*]1,5
刊名	MOLECULAR BIOLOGY AND EVOLUTION
	2011
卷号	28 期号:1 页码:39-44
关键词	purifying selection functional constraint mitochondrial-encoded protein
通讯作者	zhangyp@mail.kiz.ac.cn
合作状况	其它
英文摘要	Mitochondria are the power plant of cells, which play critical roles not only in energy metabolism but also in thermoregulation. These two roles have been individually suggested to influence mitochondrial DNA (mtDNA) evolution, however their relative importance is still rarely considered. Here, we conduct a comparative genomic analysis of 401 teleost complete mitochondrial genomes and test the roles of these dual functional constraints on mitochondria to provide a more complete view of mtDNA evolution. We found that mitochondrial protein-coding genes of migratory fishes have significantly smaller Ka/Ks than nonmigratory fishes. The same data set showed that the genes of fishes living in cold climates have significantly smaller Ka/Ks than tropical fishes. In contrast, these trends were not observed for two nuclear genes that are not involved in energy metabolism. The differences in selection patterns observed between mitochondrial and nuclear genes suggest that the functional constraints acting on mitochondria, due to energy metabolism and/or thermoregulation, influence the evolution of mitochondrial-encoded proteins in teleosts.
收录类别	SCI
资助信息	This work was supported by grants from National Basic Research Program of China (973 Pro- gram, 2007CB411600), National Natural Science Founda- tion of China (30621092), and Bureau of Science and Technology of Yunnan Province.
语种	英语
公开日期	2011-03-17
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/353002/6588]
专题	昆明动物研究所_分子进化基因组学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, China 2.Graduate School of the Chinese Academy of Sciences, Beijing, China 3.Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada 4.Banting and Best Diabetes Centre, University of Toronto, Ontario, Canada 5.Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming, China
推荐引用方式 GB/T 7714	Sun YB,Shen YY,Irwin DM,et al. Evaluating the Roles of Energetic Functional Constraints on Teleost Mitochondrial-Encoded Protein Evolution[J]. MOLECULAR BIOLOGY AND EVOLUTION,2011,28(1):39-44.
APA	Sun YB,Shen YY,Irwin DM,&Zhang YP[*].(2011).Evaluating the Roles of Energetic Functional Constraints on Teleost Mitochondrial-Encoded Protein Evolution.MOLECULAR BIOLOGY AND EVOLUTION,28(1),39-44.
MLA	Sun YB,et al."Evaluating the Roles of Energetic Functional Constraints on Teleost Mitochondrial-Encoded Protein Evolution".MOLECULAR BIOLOGY AND EVOLUTION 28.1(2011):39-44.