Mitochondrial genome evidence reveals successful Late Paleolithic settlement on the Tibetan Plateau

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 分子进化基因组学

	Mitochondrial genome evidence reveals successful Late Paleolithic settlement on the Tibetan Plateau
	Zhao M 1,2; Kong QP[*]1,3; Wang HW 4; Peng MS 1,2; Xie XD 5; Wang WZ 1,2; Jiayang 6; Duan JG 7; Cai MC 8; Zhao SN 8
刊名	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
	2009
卷号	106 期号:50 页码:21230-21235
关键词	mtDNA origin
ISSN号	0027-8424
通讯作者	kongqp@yahoo.com.cn ; zhangyp@mail.kiz.ac.cn
合作状况	其它
英文摘要	Due to its numerous environmental extremes, the Tibetan Plateau -the world's highest plateau-is one of the most challenging areas of modern human settlement. Archaeological evidence dates the earliest settlement on the plateau to the Late Paleolithic, while previous genetic studies have traced the colonization event(s) to no earlier than the Neolithic. To explore whether the genetic continuity on the plateau has an exclusively Neolithic time depth, we studied mitochondrial DNA (mtDNA) genome variation within 6 regional Tibetan populations sampled from Tibet and neighboring areas. Our results confirm that the vast majority of Tibetan matrilineal components can trace their ancestry to Epipaleolithic and Neolithic immigrants from northern China during the mid-Holocene. Significantly, we also identified an infrequent novel haplogroup, M16, that branched off directly from the Eurasian M founder type. Its nearly exclusive distribution in Tibetan populations and ancient age (>21 kya) suggest that M16 may represent the genetic relics of the Late Paleolithic inhabitants on the plateau. This partial genetic continuity between the Paleolithic inhabitants and the contemporary Tibetan populations bridges the results and inferences from archaeology, history, and genetics.
收录类别	SCI
资助信息	This work was supported by grants from the National Natural Science Foundation of China (30900797 and 30621092), the Chinese Academy of Sciences (Special Grant for the President Scholarship Winner), the Natural Science Foundation of Yunnan Province, and the Kunming Institute of Zool- ogy, CAS (Special Grant for Young Researchers).
语种	英语
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/4307]
专题	昆明动物研究所_分子进化基因组学昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_遗传资源与进化国家重点实验室昆明动物研究所_分子人类学昆明动物研究所_重大疾病机理的遗传学昆明动物研究所_生命条形码中心
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan Province, China 2.Graduate School of the Chinese Academy of Sciences, Beijing 100049, China 3.KIZ/CUHK, Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming 650223, China 4.Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming 650091, Yunnan Province, China 5.Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Science, Lanzhou University, Lanzhou 730000, Gansu Province, China 6.Clinical Laboratory, People’s Hospital of Shigatse Prefecture, Shigatse 857000, Tibet Autonomous Region, China 7.Clinical Laboratory, People’s Hospital of Nakchu Prefecture, Nakchu 852000, Tibet Autonomous Region, China 8.Blood Center of Liangshan Yi Autonomous Prefecture, Xichang 615000, Sichuan Province, China 9.Blood Center of Tibet, Lhasa 850000, Tibet Autonomous Region, China 10.Yunnan Kunming Blood Center, Kunming 650106, Yunnan Province, China
推荐引用方式 GB/T 7714	Zhao M,Kong QP[*],Wang HW,et al. Mitochondrial genome evidence reveals successful Late Paleolithic settlement on the Tibetan Plateau[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2009,106(50):21230-21235.
APA	Zhao M.,Kong QP[].,Wang HW.,Peng MS.,Xie XD.,...&Zhang YP[].(2009).Mitochondrial genome evidence reveals successful Late Paleolithic settlement on the Tibetan Plateau.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,106(50),21230-21235.
MLA	Zhao M,et al."Mitochondrial genome evidence reveals successful Late Paleolithic settlement on the Tibetan Plateau".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106.50(2009):21230-21235.