EphA7 modulates apical constriction of hindbrain neuroepithelium during neurulation in Xenopus

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	EphA7 modulates apical constriction of hindbrain neuroepithelium during neurulation in Xenopus
	Wang XL 1,2; Sun J 1,3; Li CC 1; Mao BY[*]1
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2016
卷号	479 期号:X 页码:759-765
关键词	Apical constriction EphA7 Focal adhesion kinase Neurulation Xenopus
通讯作者	mao@mail.kiz.ac.cn
合作状况	其它
英文摘要	Eph receptor tyrosine kinases (RTKs) and their ephrin ligands play multiple roles in the developing nervous system, including cell segregation, axon guidance and synaptic plasticity. Here we report the expression and function of EphA7 in Xenopus hindbrain development. EphA7 is specifically expressed in the hindbrain throughout neurulation in Xenopus embryos. Knockdown of EphA7 by specific morpholino oligonucleotide (MO) disrupted cranial neural tube closure and disturbed apical constriction of hindbrain neuroepithelial cells, indicating weakened cell surface tension. In neural plate explants, EphA7 knockdown inhibited apical filamentous actin (F-actin) accumulation. We further showed that EphA7 is involved in the phosphorylation and activation of focal adhesion kinase (FAK) in vivo and in vitro, a key regulator of actin assembly. Our findings reveal that EphA7 functions as a critical regulator of apical constriction of hindbrain neuroepithelial cells.
收录类别	SCI
资助信息	This work was supported by a grant from the National Natural Science Foundation of China (31271566).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10569]
专题	昆明动物研究所_发育生物学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650203, China 3.Present address: Laboratory of Cell and Developmental Signaling, National Cancer Institute, National Institute of Health, Frederick, Maryland 21702, USA.
推荐引用方式 GB/T 7714	Wang XL,Sun J,Li CC,et al. EphA7 modulates apical constriction of hindbrain neuroepithelium during neurulation in Xenopus[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016,479(X):759-765.
APA	Wang XL,Sun J,Li CC,&Mao BY[*].(2016).EphA7 modulates apical constriction of hindbrain neuroepithelium during neurulation in Xenopus.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,479(X),759-765.
MLA	Wang XL,et al."EphA7 modulates apical constriction of hindbrain neuroepithelium during neurulation in Xenopus".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 479.X(2016):759-765.