Prokineticin 2 Plays a Pivotal Role in Psoriasis

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	Prokineticin 2 Plays a Pivotal Role in Psoriasis
	He XQ 1; Shen CB 1,2; He L 4; Bei RZ 5; Zheng J 6; Luan N 7; Zhang ZY 1; Rong MQ[]1; Lu QM 1; Lai R[]1
刊名	EBioMedicine
	2016
卷号	13 期号:X 页码:248-261
关键词	Angiogenesis Cell proliferation Inflammation Interleukin-1 Prokineticin2 Psoriasis
通讯作者	rongmingqiang@mail.kiz.ac.cn ; rlai@mail.kiz.ac.cn
英文摘要	Psoriasis is histologically characterized by keratinocytes (KC) hyperproliferation, inflammation, and increased angiogenesis, but the pathological factor responsible for these symptoms is unknown. Here, a neuroendocrine peptide (prokineticin 2, PK2), is highly expressed in human and mouse psoriatic skins but no significant change in other autoimmune diseases, suggesting that PK2 is a psoriasis-specific factor. Bacterial products significantly up-regulated PK2, implying that infection induces PK2 over-expression. PK2 promoted KC and macrophage to produce interleukin-1 (IL-1), the central player of inflammation and psoriasis, which acts on adjacent fibroblast to induce inflammatory cascades and KC hyperproliferation. IL-1 feeds back on macrophages to induce PK2 production to perpetuate PK2-IL-1 positive feedback loop. PK2 also promoted angiogenesis, another psoriatic symptom. In mouse models, PK2 over-expression aggravated psoriasis while its knock-down inhibited pathological development. The results indicate that PK2 over-production perpetuates psoriatic symptoms by creating PK-2-IL-1 vicious loop. PK2 is a central player in psoriasis and a promising psoriasis-specific target.
收录类别	SCI
资助信息	This work was supported by funding from MOST (2013CB911300), NSFC (U1132601, 31200590), CAS (XDB13000000, XDA12020334, KSZD-EW-Z-007) and Yunnan Province (2012BC009).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10676]
专题	昆明动物研究所_动物毒素室昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kun- ming 650223, Yunnan, China 2.University of Chinese Academy of Sciences, Beijing 100009, China 3.State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China 4.The Department of dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China 5.The Department of Pathology, The Affiliated Hospital of Jiangnan University Wuxi 4th People's Hospital, Wuxi 214062, Jiangsu, China 6.Department of Physiology and Membrane Biology, University of California, Davis, California 95616, United States 7.Life Sciences College of Nanjing Agricultural University, Nanjing 210095, Jiangsu, China
推荐引用方式 GB/T 7714	He XQ,Shen CB,He L,et al. Prokineticin 2 Plays a Pivotal Role in Psoriasis[J]. EBioMedicine,2016,13(X):248-261.
APA	He XQ.,Shen CB.,He L.,Bei RZ.,Zheng J.,...&Wei YQ.(2016).Prokineticin 2 Plays a Pivotal Role in Psoriasis.EBioMedicine,13(X),248-261.
MLA	He XQ,et al."Prokineticin 2 Plays a Pivotal Role in Psoriasis".EBioMedicine 13.X(2016):248-261.