Analysis of common genetic variants identifies RELN as a risk gene for schizophrenia in Chinese population

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	Analysis of common genetic variants identifies RELN as a risk gene for schizophrenia in Chinese population
	Li M 1,4; Luo XJ 1,4; Xiao X 1; Shi LM 1,4; Liu XY 2; Yin LD 2; Ma XY 2; Yang SY 2; Pu XF 2; Yu J 3
刊名	WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
	2013
卷号	14 期号:2 页码:91-99
关键词	RELN single nucleotide polymorphism haplotype schizophrenia Chinese population
通讯作者	sub@mail.kiz.ac.cn
合作状况	其它
英文摘要	Objectives. Several lines of evidence have shown that both RELN mRNA and protein are possibly down-regulated in the brain of schizophrenia patients. Recent association studies in European populations suggested RELN as a risk gene for schizophrenia. In this study, we test if RELN contributes to the risk of schizophrenia in Chinese population. Methods. We conducted case-control association analysis of 19 representative single nucleotide polymorphisms (SNPs) spanning the entire region of RELN in two independent Han Chinese samples from southwestern China (the Kunming sample and the Yuxi sample). Results. We identified six SNPs significantly associated with schizophrenia in the Kunming sample and four of them remained significant in the combined samples (the P values range from 0.006 to 4.0 x 10(-5)). Haplotype analysis also suggested significant associations for the haplotypes incorporating the six significant SNPs (global P < 1.0 x 10(-5)). Additionally, we also observed several other haplotypes (defined by a different set of SNPs) significantly associated with schizophrenia in the Kunming sample. However, the reported association of rs7341475 in Ashkenazi Jews was not significant in Han Chinese. Conclusions : Our findings demonstrate that RELN is a susceptibility gene for schizophrenia in Chinese population, and it is likely a common risk gene for schizophrenia in major populations worldwide.
收录类别	SCI
资助信息	This work was supported by grants from the National 973 project of China (grant numbers, 2011CBA00401 and 2007CB947701), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Founda- tion of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107).
语种	英语
WOS记录号	WOS:000315898700003
公开日期	2013-04-08
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7291]
专题	昆明动物研究所_比较基因组学昆明动物研究所_遗传资源与进化国家重点实验室昆明动物研究所_神经系统疾病昆明动物研究所_转化基因组
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.The Second People’s Hospital of Yuxi City, Yuxi, China 3.Yunnan Mental Health Hospital, Kunming, China 4.Graduate School of Chinese Academy of Sciences, Beijing, China
推荐引用方式 GB/T 7714	Li M,Luo XJ,Xiao X,et al. Analysis of common genetic variants identifies RELN as a risk gene for schizophrenia in Chinese population[J]. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY,2013,14(2):91-99.
APA	Li M.,Luo XJ.,Xiao X.,Shi LM.,Liu XY.,...&Su B[*].(2013).Analysis of common genetic variants identifies RELN as a risk gene for schizophrenia in Chinese population.WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY,14(2),91-99.
MLA	Li M,et al."Analysis of common genetic variants identifies RELN as a risk gene for schizophrenia in Chinese population".WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY 14.2(2013):91-99.