Comparative analysis of CpG islands in four fish genomes

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 比较基因组学

	Comparative analysis of CpG islands in four fish genomes
	Han L 1,2,3; Zhao ZM[*]1,4,5
刊名	COMPARATIVE AND FUNCTIONAL GENOMICS
	2008
期号	X 页码:e565631
ISSN号	1531-6912
通讯作者	zzhao@vcu.edu
合作状况	其它
英文摘要	There has been much interest in CpG islands (CGIs), clusters of CpG dinucleotides in GC-rich regions, because they are considered gene markers and involved in gene regulation. To date, there has been no genome-wide analysis of CGIs in the fish genome. We first evaluated the performance of three popular CGI identification algorithms in four fish genomes (tetraodon, stickleback, medaka, and zebrafish). Our results suggest that Takai and Jones' (2002) algorithm is most suitable for comparative analysis of CGIs in the fish genome. Then, we performed a systematic analysis of CGIs in the four fish genomes using Takai and Jones' algorithm, compared to other vertebrate genomes. We found that both the number of CGIs and the CGI density vary greatly among these genomes. Remarkably, each fish genome presents a distinct distribution of CGI density with some genomic factors (e. g., chromosome size and chromosome GC content). These findings are helpful for understanding evolution of fish genomes and the features of fish CGIs.
收录类别	SCI
资助信息	This project was supported by the Thomas F. and Kate Miller Jeffress Memorial Trust Fund and a NARSAD Young Investigator Award to Z. Zhao.
原文出处	2008565631.pdf
语种	英语
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/5519]
专题	昆明动物研究所_比较基因组学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 3.Graduate School, Chinese Academy of Sciences, Beijing 100039, China 4.Department of Human Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA 5.Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA 23284, USA
推荐引用方式 GB/T 7714	Han L,Zhao ZM[*]. Comparative analysis of CpG islands in four fish genomes[J]. COMPARATIVE AND FUNCTIONAL GENOMICS,2008(X):e565631.
APA	Han L,&Zhao ZM[*].(2008).Comparative analysis of CpG islands in four fish genomes.COMPARATIVE AND FUNCTIONAL GENOMICS(X),e565631.
MLA	Han L,et al."Comparative analysis of CpG islands in four fish genomes".COMPARATIVE AND FUNCTIONAL GENOMICS .X(2008):e565631.