Thiopeptide Antibiotics Exhibit a Dual Mode of Action against Intracellular Pathogens by Affecting Both Host and Microbe

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	Thiopeptide Antibiotics Exhibit a Dual Mode of Action against Intracellular Pathogens by Affecting Both Host and Microbe
	Zheng QF(郑庆飞)1; Wang QL(王晴岚)1; Wang SF(王守峰)1; Wu JQ(吴杰群)1; Gao Q(高谦)1; Liu W(刘文)1
刊名	Chem. Biol.
	2015
卷号	22 期号:8 页码:1002-1007
其他题名	硫肽类抗生素通过影响宿主和微生物表现出抑制细胞内病原体的双重作用模式
通讯作者	高谦 ; 刘文
英文摘要	Thiostrepton (TSR) is an archetypal thiopeptide antibiotic possessing a quinaldic acid (QA) moiety in the side ring system. According to the mechanism of TSR previously known to target bacterial ribosome, we recently designed and biosynthesized several TSR derivatives that varied in QA substitution. Utilizing these thiopeptide antibiotics to treat the intracellular pathogen Mycobacterium marinum, we herein report a novel mode of action of TSRs, which induce ER stress-mediated autophagy to enhance host cell defense. This intracellular response, which is sensitive to the modification of the QA group, serves as an indirect but unignorable mechanism for eliminating intracellular pathogens. TSRs are thus the only type of antibiotics, to our knowledge, with the dual action on both the parasitic bacteria and the infected host cells. The newly observed mechanism of TSRs may inspire the future change in the treatment of intracellular pathogens, by taking host response into account.
学科主题	生命有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1016/j.chembiol.2015.06.019
语种	英语
WOS记录号	WOS:000361879200006
内容类型	期刊论文
源URL	[http://ir.sioc.ac.cn/handle/331003/39526]
专题	上海有机化学研究所_生命有机化学国家重点实验室
作者单位	1.中科院上海有机化学研究所, 生命有机化学国家重点实验室 2.复旦大学 3.湖州生物制造创新中心
推荐引用方式 GB/T 7714	Zheng QF,Wang QL,Wang SF,et al. Thiopeptide Antibiotics Exhibit a Dual Mode of Action against Intracellular Pathogens by Affecting Both Host and Microbe[J]. Chem. Biol.,2015,22(8):1002-1007.
APA	郑庆飞,王晴岚,王守峰,吴杰群,高谦,&刘文.(2015).Thiopeptide Antibiotics Exhibit a Dual Mode of Action against Intracellular Pathogens by Affecting Both Host and Microbe.Chem. Biol.,22(8),1002-1007.
MLA	郑庆飞,et al."Thiopeptide Antibiotics Exhibit a Dual Mode of Action against Intracellular Pathogens by Affecting Both Host and Microbe".Chem. Biol. 22.8(2015):1002-1007.