Highly Regio- and Enantioselective Synthesis of N-Substituted 2-Pyridones: Iridium-Catalyzed Intermolecular Asymmetric Allylic Amination

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	Highly Regio- and Enantioselective Synthesis of N-Substituted 2-Pyridones: Iridium-Catalyzed Intermolecular Asymmetric Allylic Amination
	Zhang X(张霄); Yang ZP(杨泽鹏); Huang L(黄林); You SL(游书力)
刊名	Angew. Chem.-Int. Edit.
	2015
卷号	54 期号:6 页码:1873-1876
其他题名	金属铱催化的不对称烯丙基胺化反应高区域选择性和对映选择性合成N-取代2-吡啶酮
通讯作者	游书力
英文摘要	The first iridium-catalyzed intermolecular asymmetric allylic amination reaction with 2-hydroxypyridines has been developed, thus providing a highly efficient synthesis of enantioenriched N-substituted 2-pyridone derivatives from readily available starting materials. This protocol features a good tolerance of functional groups in both the allylic carbonates and 2-hydroxypyridines, thereby delivering multifunctionalized heterocyclic products with up to 98% yield and 99%ee.
学科主题	金属有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1002/anie.201409976
语种	英语
WOS记录号	WOS:000349209200035
内容类型	期刊论文
源URL	[http://ir.sioc.ac.cn/handle/331003/39564]
专题	上海有机化学研究所_金属有机化学国家重点实验室
作者单位	中科院上海有机化学研究所, 金属有机化学国家重点实验室
推荐引用方式 GB/T 7714	Zhang X,Yang ZP,Huang L,et al. Highly Regio- and Enantioselective Synthesis of N-Substituted 2-Pyridones: Iridium-Catalyzed Intermolecular Asymmetric Allylic Amination[J]. Angew. Chem.-Int. Edit.,2015,54(6):1873-1876.
APA	张霄,杨泽鹏,黄林,&游书力.(2015).Highly Regio- and Enantioselective Synthesis of N-Substituted 2-Pyridones: Iridium-Catalyzed Intermolecular Asymmetric Allylic Amination.Angew. Chem.-Int. Edit.,54(6),1873-1876.
MLA	张霄,et al."Highly Regio- and Enantioselective Synthesis of N-Substituted 2-Pyridones: Iridium-Catalyzed Intermolecular Asymmetric Allylic Amination".Angew. Chem.-Int. Edit. 54.6(2015):1873-1876.