Rational design of multi-targeting ruthenium- and platinum-based anticancer complexes

	Rational design of multi-targeting ruthenium- and platinum-based anticancer complexes
	Zheng, Wei 1,2,3,4,5; Zhao, Yao 1,2,3,4,5; Luo, Qun 1,2,3,4,5; Zhang, Yang 1,2,3,4,5; Wu, Kui 1,2,3,4,5; Wang, Fuyi 1,2,3,4,5
刊名	SCIENCE CHINA-CHEMISTRY
	2016-10-01
卷号	59 期号:10 页码:1240-1249
关键词	anticancer agents metal complexes multi-targeting EGFR-inhibition DNA binding
英文摘要	Platinum-based anticancer drugs, including cisplatin and its analogues, have played important roles in the clinical treatment of solid tumors over the past 38 years. However, poor selectivity, high toxicity and intrinsic or acquired drug resistance profoundly limit their application, which encourages the development of novel transition metal-based anticancer agents with different mechanisms of action. To this end, transition metal complexes that can simultaneously act on more than one target, termed as single-molecule multi-targeting complexes, have attracted increasing attention because of their enhanced efficacy and diminished chance of drug resistance. In this review, we systematically discuss the recent progress in the development of platinum- and ruthenium-based anticancer agents, in particular the rational design of platinum and ruthenium complexes with multi-targeting features.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/35644]
专题	化学研究所_活体分析化学实验室
作者单位	1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, CAS Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Natl Ctr Mass Spectrometry Beijing, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zheng, Wei,Zhao, Yao,Luo, Qun,et al. Rational design of multi-targeting ruthenium- and platinum-based anticancer complexes[J]. SCIENCE CHINA-CHEMISTRY,2016,59(10):1240-1249.
APA	Zheng, Wei,Zhao, Yao,Luo, Qun,Zhang, Yang,Wu, Kui,&Wang, Fuyi.(2016).Rational design of multi-targeting ruthenium- and platinum-based anticancer complexes.SCIENCE CHINA-CHEMISTRY,59(10),1240-1249.
MLA	Zheng, Wei,et al."Rational design of multi-targeting ruthenium- and platinum-based anticancer complexes".SCIENCE CHINA-CHEMISTRY 59.10(2016):1240-1249.