An easy-to-use wound dressing gelatin-bioactive nanoparticle gel and its preliminary in vivo study

	An easy-to-use wound dressing gelatin-bioactive nanoparticle gel and its preliminary in vivo study
	Wang, Chen 1,2; Zhu, Feiyan 2; Cui, Yang 1,2; Ren, Huihui 1,2; Xie, Yue 1; Li, Ailing 1; Ji, Lijun 3; Qu, Xiaozhong 2; Qiu, Dong 1,2; Yang, Zhenzhong 1
刊名	JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
	2017
卷号	28 期号:1
英文摘要	Beyond promoting hard tissue repairing, bioactive glasses (BGs) have also been proved to be beneficial for wound healing. Nano-scale BGs prepared by sol-gel method were found to have a better performance as they have a larger specific surface area. In this work, bioactive nanoparticles (nBPs) with mean diameter of 12 nm (BP-12) instead of conventional BGs were mixed with gelatin to form an easy-to-use hydrogel as a dressing for skin wound. It was found that the composite of BP-12 and gelatin could form a hydrogel (BP-12/Gel) under 25 degrees C, which showed pronounced thixotropy at a practically accessible shear rate, therefore become easy to be used for wound cover. In vitro, the composite hydrogel of BP-12 and gelatin had good biocompatibility with the fibroblast cells. In vivo, rapid cutaneous-tissue regeneration and tissue-structure formation within 7 days was observed in the wound-healing experiment performed in rats. This hydrogel is thus a promising easy-to-use wound dressing material.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/36330]
专题	化学研究所_高分子物理与化学实验室
作者单位	1.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100190, Peoples R China 3.Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Wang, Chen,Zhu, Feiyan,Cui, Yang,et al. An easy-to-use wound dressing gelatin-bioactive nanoparticle gel and its preliminary in vivo study[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2017,28(1).
APA	Wang, Chen.,Zhu, Feiyan.,Cui, Yang.,Ren, Huihui.,Xie, Yue.,...&Yang, Zhenzhong.(2017).An easy-to-use wound dressing gelatin-bioactive nanoparticle gel and its preliminary in vivo study.JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,28(1).
MLA	Wang, Chen,et al."An easy-to-use wound dressing gelatin-bioactive nanoparticle gel and its preliminary in vivo study".JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 28.1(2017).