A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses | |
Zha, Jun1,2; Liu, Xiang-meng1,3; Zhu, Jie1; Liu, Shu-ying1,4; Lu, Shuai1; Xu, Peng-xin4; Yu, Xiao-lin1; Liu, Rui-tian1 | |
刊名 | SCIENTIFIC REPORTS |
2016-11-08 | |
卷号 | 6期号:NOV页码:36631 |
ISSN号 | 2045-2322 |
英文摘要 | Overproduction or poor clearance of amyloids lead to amyloid aggregation and even amyloidosis development. Different amyloids may interact synergistically to promote their aggregation and accelerate pathology in amyloidoses. Amyloid oligomers assembled from different amyloids share common structures and epitopes, and are considered the most toxic species in the pathologic processes of amyloidoses, which suggests that an agent targeting the common epitope of toxic oligomers could provide benefit to several amyloidoses. In this study, we firstly showed that an oligomer-specific single-chain variable fragment antibody, W20 simultaneously improved motor and cognitive function in Parkinson's disease and Huntington's disease mouse models, and attenuated a number of neuropathological features by reducing alpha-synuclein and mutant huntingtin protein aggregate load and preventing synaptic degeneration. Neuroinflammation and oxidative stress in vivo were also markedly inhibited. The proposed strategy targeting the common epitopes of amyloid oligomers presents promising potential for treating Parkinson's disease, Huntington's disease, Alzheimer's disease, and other amyloidoses. |
WOS标题词 | Science & Technology |
类目[WOS] | Multidisciplinary Sciences |
研究领域[WOS] | Science & Technology - Other Topics |
关键词[WOS] | HUMAN ALPHA-SYNUCLEIN ; DISEASE TRANSGENIC MICE ; RESCUES MEMORY DEFICITS ; HUNTINGTONS-DISEASE ; ALZHEIMERS-DISEASE ; MOUSE MODEL ; MUTANT HUNTINGTIN ; OXIDATIVE STRESS ; A-BETA ; NEURODEGENERATIVE DISEASES |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000387323000001 |
内容类型 | 期刊论文 |
源URL | [http://ir.ipe.ac.cn/handle/122111/21654] |
专题 | 过程工程研究所_生化工程国家重点实验室 |
作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China 2.China Pharmaceut Univ, Sch Pharm, Nanjing, Jiangsu, Peoples R China 3.Qilu Univ Technol, Sch Bioengn, Jinan, Peoples R China 4.Ningxia Univ, Sch Life Sci, Yinchuan, Peoples R China |
推荐引用方式 GB/T 7714 | Zha, Jun,Liu, Xiang-meng,Zhu, Jie,et al. A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses[J]. SCIENTIFIC REPORTS,2016,6(NOV):36631. |
APA | Zha, Jun.,Liu, Xiang-meng.,Zhu, Jie.,Liu, Shu-ying.,Lu, Shuai.,...&Liu, Rui-tian.(2016).A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses.SCIENTIFIC REPORTS,6(NOV),36631. |
MLA | Zha, Jun,et al."A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses".SCIENTIFIC REPORTS 6.NOV(2016):36631. |
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