Antifungal New Oxepine-Containing Alkaloids and Xanthones from the Deep-Sea-Derived Fungus Aspergillus versicolor SCSIO 05879

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	Antifungal New Oxepine-Containing Alkaloids and Xanthones from the Deep-Sea-Derived Fungus Aspergillus versicolor SCSIO 05879
	Wang, Junfeng; He, Weijun; Huang, Xiaolong; Tian, Xinpeng; Liao, Shengrong; Yang, Bin; Wang, Fazuo; Zhou, Xiaojiang; Liu, Yonghong
刊名	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
	2016
卷号	64 期号:14 页码:2910-2916
关键词	deep-sea-derived Aspergillus versicolor ECD calculations oxepine phytopathogenic fungi antifungal activities
通讯作者	Liu, YH (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol,RNAM Ctr Marine Micr, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Guangdong, Peoples R China.
中文摘要	Phytopathogenic fungi remain a continuous and huge threat in the agricultural fields. The agrochemical industry has made great development of the use of microbial natural products, which has been regarded as an effective strategy against phytopathogenic fungi. Antifungal bioassay-directed fractionation was used to isolate two new oxepine-containing alkaloids (1 and 2), two new 4-aryl-quinolin-2-one alkaloids (3 and 4), and four new prenylated xanthones (5-8) from the deep-sea-derived fungus Aspergillus versicolor SCSIO 05879. Extensive NMR spectroscopic analysis, quantum mechanical calculations, and X-ray single-crystal diffraction were used to elucidate their structures, including their absolute configurations. Versicoloids A and B, versicone A, and cottoquinazoline A showed antifungal activities against three phytopathogenic fungi. The antifungal activities of these bioactive compounds strongly depend on the fungal species. Especially versicoloids A and B showed strong fungicidal effect (AEC of 1.6 mu g/mL) against Colletotrichum acutatum, compared with that of the positive control cydoheximide (MIC of 6.4 mu g/mL). The results of antifungal experiments indicated that versicoloids A and B may be regarded as candidate agents of antifungal agro chemicals.
学科主题	Agriculture; Chemistry; Food Science & Technology
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/15464]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Wang, Junfeng,He, Weijun,Huang, Xiaolong,et al. Antifungal New Oxepine-Containing Alkaloids and Xanthones from the Deep-Sea-Derived Fungus Aspergillus versicolor SCSIO 05879[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2016,64(14):2910-2916.
APA	Wang, Junfeng.,He, Weijun.,Huang, Xiaolong.,Tian, Xinpeng.,Liao, Shengrong.,...&Liu, Yonghong.(2016).Antifungal New Oxepine-Containing Alkaloids and Xanthones from the Deep-Sea-Derived Fungus Aspergillus versicolor SCSIO 05879.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,64(14),2910-2916.
MLA	Wang, Junfeng,et al."Antifungal New Oxepine-Containing Alkaloids and Xanthones from the Deep-Sea-Derived Fungus Aspergillus versicolor SCSIO 05879".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 64.14(2016):2910-2916.