Design, synthesis and biological evaluation of soluble 2,5-diketopiperazines derivatives as potential antifouling agents | |
Liao, Shengrong1; Xu, Ying1; Tang, Yong1; Wang, Junfeng1; Zhou, Xuefeng1; Xu, Liang1; Liu, Yonghong1 | |
刊名 | RSC ADVANCES
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2015 | |
卷号 | 5期号:63页码:51020-51026 |
通讯作者 | ljrss@126.com ; boxuying@szu.edu.cn ; 307091847@qq.com ; junfeng1982a@163.com ; xfzhou@scsio.ac.cn ; xuliang@enantiotech.net ; yonghongliu@scsio.ac.cn |
英文摘要 | A small library of soluble 2,5-diketopiperazine derivatives were designed, synthesized and evaluated as antifouling agents against two species of marine organisms: Balanus amphitrite and Bugula neritina by larval attachment assay. The results showed that different derivatives had different antifouling activities. Among these compounds, 3a (EC50 = 2.5 mu g mL(-1)), 3b (EC50 = 3.2 mg mL(-1)) and 3d (EC50 = 1.6 mg mL(-1)) had strong activities, and 2d (EC50 = 20.5 mg mL(-1)), 3l (EC50 = 25.0 mg mL(-1)) and 3m (EC50 = 18.5 mg mL(-1)) had moderate activities against Balanus amphitrite, but other compounds had no activities. Differently, compounds 3d (EC50 = 3.1 mg mL(-1)) and 3i (EC50 = 2.3 mg mL(-1)) exhibited strong activities, and 3a (EC50 = 11.3 mg mL(-1)) and 3c (EC50 = 17.2 mg mL(-1)) showed moderate activities against Bugula neritina, whereas other compounds had no activities. All of the active compounds had stronger antifouling activities than those of the natural product cyclo-(L-Phe-L-Pro). Compound 3d could be a new template molecule for further development as an antifouling agent because of its strong inhibitory activities against both species of fouling organisms with low or no toxicity to the environment. |
学科主题 | Chemistry |
原文出处 | 2046-2069 |
内容类型 | 期刊论文 |
源URL | [http://ir.scsio.ac.cn/handle/344004/14891] ![]() |
专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
作者单位 | 1.[Liao, Shengrong 2.Tang, Yong 3.Wang, Junfeng 4.Zhou, Xuefeng 5.Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,Res Ctr Marine M, Guangzhou 510301, Guangdong, Peoples R China 6.[Xu, Ying] Shenzhen Univ, Coll Life Sci, Shenzhen Engn Lab Marine Algal Biotechnol, Shenzhen Key Lab Marine Bioresource & Ecoenvironm, Shenzhen 518060, Peoples R China 7.[Xu, Liang] Enantiotech Corp Ltd, Zhongshan Torch Hitech, Zhongshan 528437, Peoples R China |
推荐引用方式 GB/T 7714 | Liao, Shengrong,Xu, Ying,Tang, Yong,et al. Design, synthesis and biological evaluation of soluble 2,5-diketopiperazines derivatives as potential antifouling agents[J]. RSC ADVANCES,2015,5(63):51020-51026. |
APA | Liao, Shengrong.,Xu, Ying.,Tang, Yong.,Wang, Junfeng.,Zhou, Xuefeng.,...&Liu, Yonghong.(2015).Design, synthesis and biological evaluation of soluble 2,5-diketopiperazines derivatives as potential antifouling agents.RSC ADVANCES,5(63),51020-51026. |
MLA | Liao, Shengrong,et al."Design, synthesis and biological evaluation of soluble 2,5-diketopiperazines derivatives as potential antifouling agents".RSC ADVANCES 5.63(2015):51020-51026. |
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