Gadolinium(III) Porpholactones as Efficient and Robust Singlet Oxygen Photosensitizers

	Gadolinium(III) Porpholactones as Efficient and Robust Singlet Oxygen Photosensitizers
	Ke, Xian-Sheng 1; Ning, Yingying 1; Tang, Juan 1; Hu, Ji-Yun 1; Yin, Hao-Yan 1; Wang, Gao-Xiang 1; Yang, Zi-Shu 1; Jie, Jialong 2; Liu, Kunhui 3; Meng, Zhao-Sha 1,4
刊名	CHEMISTRY-A EUROPEAN JOURNAL
	2016-07-04
卷号	22 期号:28 页码:9676-9686
关键词	gadolinium photocatalysis photocytotoxicity singlet oxygen tetrapyrrole
英文摘要	Construction of Gd-III photosensitizers is important for designing theranostic agents owing to the unique properties arising from seven unpaired f electrons of the Gd3+ ion. Combining these with the advantages of porpholactones with tunable NIR absorption, we herein report the synthesis of Gd-III complexes Gd-1-4 (1, porphyrin; 2, porpholactone; 3 and 4, cis- and trans-porphodilactone, respectively) and investigated their function as singlet oxygen (O-1(2)) photosensitizers. These Gd complexes displayed O-1(2) quantum yields (Phi(Delta)s) from 0.64-0.99 with the order Gd-1< Gd-2< Gd-3< Gd-4. The gradually enhanced O-1(2) sensitization after beta-oxazolone moiety replacement was ascribed to the narrowing of the energy gap (Delta E) between the lowest triplet states (T-1) of the ligand and the energy level of the (1)Delta(g) -> (3)Sigma(g) transition of O-1(2). In particular, Gd-4 is capable of excitation in the visible to NIR region (400-700 nm) with a quantum yield near unity. These Gd complexes were first demonstrated as efficient photosensitizers in photocatalysis such as oxidative C-H bond functionalization of secondary or tertiary amines, and the oxygenation of the natural product cholesterol. Finally, after glycosylation, these water-soluble Gd complexes showed potential applications in photodynamic therapy (PDT) in HeLa cells. This work revealed that Gd-III complexes of "bioinspired" beta-modified porpholactones are efficient NIR photosensitizers and form a chemical basis to construct appealing photocatalysts and theranostic agents based on lanthanides.
收录类别	SCI ; IC
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/35206]
专题	化学研究所_光化学实验室
作者单位	1.Peking Univ, Coll Chem & Mol Engn, State Key Lab Rare Earth Mat Chem & Applicat, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 3.Beijing Normal Univ, Coll Chem, Beijing 100875, Peoples R China 4.Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China 5.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Ke, Xian-Sheng,Ning, Yingying,Tang, Juan,et al. Gadolinium(III) Porpholactones as Efficient and Robust Singlet Oxygen Photosensitizers[J]. CHEMISTRY-A EUROPEAN JOURNAL,2016,22(28):9676-9686.
APA	Ke, Xian-Sheng.,Ning, Yingying.,Tang, Juan.,Hu, Ji-Yun.,Yin, Hao-Yan.,...&Zhang, Jun-Long.(2016).Gadolinium(III) Porpholactones as Efficient and Robust Singlet Oxygen Photosensitizers.CHEMISTRY-A EUROPEAN JOURNAL,22(28),9676-9686.
MLA	Ke, Xian-Sheng,et al."Gadolinium(III) Porpholactones as Efficient and Robust Singlet Oxygen Photosensitizers".CHEMISTRY-A EUROPEAN JOURNAL 22.28(2016):9676-9686.