Bioreducible Gene Delivery Vector Capable of Self-Scavenging the Intracellular-Generated ROS Exhibiting High Gene Transfection

	Bioreducible Gene Delivery Vector Capable of Self-Scavenging the Intracellular-Generated ROS Exhibiting High Gene Transfection
	Wang, Long-Hai 1; Wu, Ting 1; Wu, De-Cheng 2; You, Ye-Zi 1
刊名	ACS APPLIED MATERIALS & INTERFACES
	2016-08-03
卷号	8 期号:30 页码:19238-19244
关键词	gene delivery self-assemble bioreducible nanomicelles reactive oxygen species self-scavenge
英文摘要	Cationic polymer vectors have received increasing attention for gene delivery in biotechnology over the past 2 decades, but few polymer vectors were used in clinical applications due to their low gene transfection efficacy. One of the major reasons is that the conventional cationic polymers can induce the increasing of intracellular reactive oxygen species (ROS) concentration and oxidative stress, which reduces the gene transfection efficacy. Here, we create a novel class of thioether dendron-branched polymer conjugate and self-assemble this conjugate into bioreducible cationic nanomicelles with disulfide bond connecting the thioether core to the cationic shell. The obtained nanomicelles have a unique ROS self-scavenging ability, thereby dramatically improving gene transfection efficacy.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/35378]
专题	化学研究所_高分子物理与化学实验室
作者单位	1.Univ Sci & Technol China, Dept Polymer Sci & Engn, Chinese Acad Sci, Key Lab Soft Matter Chem, Hefei 230026, Anhui, Peoples R China 2.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Wang, Long-Hai,Wu, Ting,Wu, De-Cheng,et al. Bioreducible Gene Delivery Vector Capable of Self-Scavenging the Intracellular-Generated ROS Exhibiting High Gene Transfection[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(30):19238-19244.
APA	Wang, Long-Hai,Wu, Ting,Wu, De-Cheng,&You, Ye-Zi.(2016).Bioreducible Gene Delivery Vector Capable of Self-Scavenging the Intracellular-Generated ROS Exhibiting High Gene Transfection.ACS APPLIED MATERIALS & INTERFACES,8(30),19238-19244.
MLA	Wang, Long-Hai,et al."Bioreducible Gene Delivery Vector Capable of Self-Scavenging the Intracellular-Generated ROS Exhibiting High Gene Transfection".ACS APPLIED MATERIALS & INTERFACES 8.30(2016):19238-19244.