Genetic lineage tracing identifies endocardial origin of liver vasculature

CORC > 上海神经科学研究所 > 中国科学院上海生命科学研究院神经科学研究所 > 神经所(总)

	Genetic lineage tracing identifies endocardial origin of liver vasculature
	Zhang, H; Pu, WJ; Tian, XY; Huang, XZ; He, LJ; Liu, QZ; Li, Y; Zhang, LB; He, L; Liu, K
刊名	NATURE GENETICS
	2016
卷号	48 期号:5 页码:537-537
关键词	ENDOTHELIAL-CELLS CORONARY-ARTERIES MOLECULAR-MECHANISMS TRANSCRIPTION FACTOR BLOOD-VESSELS NF-ATC VEGF-A ANGIOGENESIS HEART SIGNALS
通讯作者	Zhou, B (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab, Inst Nutr Sci,Grad Sch, Shanghai, Peoples R China. ; Zhou, B (reprint author), ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China. ; Zhou, B (reprint author), Chinese Acad Sci, State Key Lab Neurosci, Ctr Excellence Brain Sci & Intelligence Technol, Inst Neurosci,Shanghai Inst Biol Sci, Shanghai, Peoples R China.,zhoubin@sibs.ac.cn
英文摘要	The hepatic vasculature is essential for liver development, homeostasis and regeneration, yet the developmental program of hepatic vessel formation and the embryonic origin of the liver vasculature remain unknown. Here we show in mouse that endocardial cells form a primitive vascular plexus surrounding the liver bud and subsequently contribute to a substantial portion of the liver vasculature. Using intersectional genetics, we demonstrate that the endocardium of the sinus venosus is a source for the hepatic plexus. Inhibition of endocardial angiogenesis results in reduced endocardial contribution to the liver vasculature and defects in liver organogenesis. We conclude that a substantial portion of liver vessels derives from the endocardium and shares a common developmental origin with coronary arteries.
学科主题	Genetics & Heredity
WOS标题词	Genetics & Heredity
语种	英语
WOS记录号	WOS:000374834100013
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/4027]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Zhang, H,Pu, WJ,Tian, XY,et al. Genetic lineage tracing identifies endocardial origin of liver vasculature[J]. NATURE GENETICS,2016,48(5):537-537.
APA	Zhang, H.,Pu, WJ.,Tian, XY.,Huang, XZ.,He, LJ.,...&Zhou, B.(2016).Genetic lineage tracing identifies endocardial origin of liver vasculature.NATURE GENETICS,48(5),537-537.
MLA	Zhang, H,et al."Genetic lineage tracing identifies endocardial origin of liver vasculature".NATURE GENETICS 48.5(2016):537-537.