Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice

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	Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice
	Wu, KY; Zuo, GL; Li, XF; Ye, Q; Deng, YQ; Huang, XY; Cao, WC; Qin, CF; Luo, ZG
刊名	CELL RESEARCH
	2016
卷号	26 期号:6 页码:645-654
关键词	INFECTION AUTISM BRAZIL BRAIN PROGENITORS NEOCORTEX AMERICA
通讯作者	Luo, ZG (reprint author), Chinese Acad Sci, Inst Neurosci, Ctr Excellence Brain Sci & Intelligence Technol, State Key Lab Neurosci,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China. ; Qin, CF (reprint author), Beijing Inst Microbiol & Epidemiol, Dept Virol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China. ; Luo, ZG (reprint author), Chinese Acad Sci Univ, Beijing, Peoples R China. ; Luo, ZG (reprint author), ShanghaiTech Univ, Shanghai, Peoples R China.,qincf@bmi.ac.cn ; zgluo@ion.ac.cn
英文摘要	The recent Zika virus (ZIKV) epidemic in Latin America coincided with a marked increase in microcephaly in newborns. However, the causal link between maternal ZIKV infection and malformation of the fetal brain has not been firmly established. Here we show a vertical transmission of ZIKV in mice and a marked effect on fetal brain development. We found that intraperitoneal (i.p.) injection of a contemporary ZIKV strain in pregnant mice led to the infection of radial glia cells (RGs) of dorsal ventricular zone of the fetuses, the primary neural progenitors responsible for cortex development, and caused a marked reduction of these cortex founder cells in the fetuses. Interestingly, the infected fetal mice exhibited a reduced cavity of lateral ventricles and a discernable decrease in surface areas of the cortex. This study thus supports the conclusion that vertically transmitted ZIKV affects fetal brain development and provides a valuable animal model for the evaluation of potential therapeutic or preventative strategies.
学科主题	Cell Biology
WOS标题词	Cell Biology
语种	英语
WOS记录号	WOS:000377449500005
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/4019]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Wu, KY,Zuo, GL,Li, XF,et al. Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice[J]. CELL RESEARCH,2016,26(6):645-654.
APA	Wu, KY.,Zuo, GL.,Li, XF.,Ye, Q.,Deng, YQ.,...&Luo, ZG.(2016).Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice.CELL RESEARCH,26(6),645-654.
MLA	Wu, KY,et al."Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice".CELL RESEARCH 26.6(2016):645-654.