Searching the Evolutionary Origin of Epithelial Mucus Protein Components-Mucins and FCGBP

CORC > 西双版纳热带植物园 > 中国科学院西双版纳热带植物园 > 能源植物分子育种研究组

	Searching the Evolutionary Origin of Epithelial Mucus Protein Components-Mucins and FCGBP
	Lang, Tiange ; Klasson, Sofia ; Larsson, Erik ; et al
刊名	MOLECULAR BIOLOGY AND EVOLUTION
	2016
卷号	33 期号:8 页码:1921-1936
关键词	mucin mucus bioinformatics evolution von Willebrand D domain
中文摘要	The gel-forming mucins are large glycosylated proteins that are essential components of the mucus layers covering epithelial cells. Using novel methods of identifying mucins based on profile hidden Markov models, we have found a large number of such proteins in Metazoa, aiding in their classification and allowing evolutionary studies. Most vertebrates have 5-6 gel-forming mucin genes and the genomic arrangement of these genes is well conserved throughout vertebrates. An exception is the frog Xenopus tropicalis with an expanded repertoire of at least 26 mucins of this type. Furthermore, we found that the ovomucin protein, originally identified in chicken, is characteristic of reptiles, birds, and amphibians. Muc6 is absent in teleost fish, but we now show that it is present in animals such as ghost sharks, demonstrating an early origin in vertebrate evolution. Public RNA-Seq data were analyzed with respect tomucins in zebrafish, frog, and chicken, thus allowing comparison in regard of tissue and developmental specificity. Analyses of invertebrate proteins reveal that gel-forming-mucin type of proteins is widely distributed also in this group. Their presence in Cnidaria, Porifera, and in Ctenophora (comb jellies) shows that these proteins were present early in metazoan evolution. Finally, we examined the evolution of the FCGBP protein, abundant in mucus and related to gel-forming mucins in terms of structure and localization. We demonstrate that FCGBP, ubiquitous in vertebrates, has a conserved N-terminal domain. Interestingly, this domain is also present as an N-terminal sequence in a number of bacterial proteins.
公开日期	2016-09-23
内容类型	期刊论文
源URL	[http://ir.xtbg.org.cn/handle/353005/10025]
专题	西双版纳热带植物园_能源植物分子育种研究组
推荐引用方式 GB/T 7714	Lang, Tiange,Klasson, Sofia,Larsson, Erik,et al. Searching the Evolutionary Origin of Epithelial Mucus Protein Components-Mucins and FCGBP[J]. MOLECULAR BIOLOGY AND EVOLUTION,2016,33(8):1921-1936.
APA	Lang, Tiange,Klasson, Sofia,Larsson, Erik,&et al.(2016).Searching the Evolutionary Origin of Epithelial Mucus Protein Components-Mucins and FCGBP.MOLECULAR BIOLOGY AND EVOLUTION,33(8),1921-1936.
MLA	Lang, Tiange,et al."Searching the Evolutionary Origin of Epithelial Mucus Protein Components-Mucins and FCGBP".MOLECULAR BIOLOGY AND EVOLUTION 33.8(2016):1921-1936.